摘要
目的 研究复方红芪提取液进行减方后对周围神经再生的作用。方法 建立钳夹损伤大鼠双侧坐骨神经的动物模型。按术后每日灌服药物的不同将 40只SD雄性大鼠随机均分为 4组。对照组 :灌服生理盐水 ;复方红芪组 :灌服复方红芪提取液 2ml ;减方组 :灌服复方红芪减方后提取液 2ml;补阳还五汤组 :灌服补阳还五汤 2ml。术后 2周及 4周 ,观察坐骨神经功能指数、运动神经传导速度及单位视野有髓神经纤维计数。结果 坐骨神经功能指数 :红芪组和减方组与对照组、红芪组与减方组的差异均有显著意义 (P >0 .0 5 ) ,且减方组优于红芪组 (P >0 .0 5 )。有髓神经纤维计数 :复方红芪组优于对照组 (P<0 0 1) ,减方组明显优于对照组 (P <0 .0 1) ,而红芪组与减方组间无显著差异。运动神经传导速度 :红芪组、减方组、补阳还五汤组与对照组相比 ,均优于对照组 (P <0 .0 5 ) ,但前 3组间无明显差异。结论 复方红芪减方提取液早期可以促进周围神经再生 ,药效更为专一 ,且优于传统方剂补阳还五汤。
Objective To investigate the effect of modified formula Radix hedysari on the peripheral nerve regeneration. Methods The sciatic nerves at 2 sides were clamped in rats. Forty male SD rats were randomly divided into 4 groups according to the different medication. Control group:normal saline;group of formula Radix hedysari et al. :take medicine of extract from formula Radix hedysari et al 2ml/d; modified group: take medicine of modified formula Radix hedysari et al. 2ml/d; group of Bu Yang Huan Wu Tang:take medicine of Bu Yang Huan Wu Tang 2ml/d. The sciatic nerve function index(SFI), the motor nerve conduction velocity(MNCV) and total myelinated axons per sight were counted on 2 and 4 weeks after the surgery. Results There were statistically significant difference in SFI in the modified formula Radix hedysari et al and modified groups vs control group. And the results in modified group was superior to that in group of formula Radix hedysari et al The results in the myelinated nerve fiber counting in group of formula Radix hedysari et al was superior to that in control group, and that in modified group was superior to that in control group. But no difference was found between that in group of formula Radix hedysari et al and in modified group. MNCV in the other 3 group was superior to that in control group. But there was no difference in these 3 groups. Conclusion The extract of modified formula Radix hedysari et al can facilitate the regeneration of peripheral nerve at the early stage. The outcome is more special and superior to that in traditional medicine of Bu Yang Huan Wu Tang.
出处
《中华手外科杂志》
CSCD
2004年第3期177-179,共3页
Chinese Journal of Hand Surgery
基金
国家自然科学基金资助项目 (70 2 2 0 2 1 )
国家 973重大基础研究前期研究资助项目 (2 0 0 3CB51 330 0)
