摘要
博落回对小鼠经口急性毒性和对大鼠腹腔注射亚慢性毒性试验结果表明:博落回生物碱硫酸盐对昆明系小鼠的急性毒性为;水溶液LD_(50)=900 mg·kg^(-1),水混悬液LD_(50)=1043 mg·kg^(-1),均属低毒级。博落回注射液对Wistar大鼠亚慢性毒作用的靶器官主要为肝,长时间或大剂量接毒引起肝细胞变性、增生,使雄性动物肝/体比明显增高,而血清谷-丙转氨酶下降。
The acute oral toxicity of Madeaya cordata (Willd) R. Br. in mice and the subchronic toxicity of it in the rats with peritoneal injection were studied. The results showed that the LD_(50) of alkaloid sulfatate of Madeave cordata (Willd) R. Br. in mice. Kunming strain, was 900mg·kg^(-1)(aqueous solution) and 1043mg·kg^(-1)(suspension). It was recognized as low-toxic drug. The target organ of Madeava cordata (Willd) R. Br. injection in the rats, wistar strain was mainly liver, resulting in hepatocyte degeneration and proliferation. The ratio of liver/body of male animals was increased, and the level of SGPT was decreased.
出处
《华中农业大学学报》
CAS
CSCD
北大核心
1993年第6期612-616,共5页
Journal of Huazhong Agricultural University
关键词
博落回
毒性
Madeays cordata (Willd) R. Br. , acute oral toxicity, subchronic toxicity, target organ, ratio of liver/body
