摘要
目的 :观察软坚清脉方对肢体动脉硬化性闭塞经皮氧分压 (TcpO2 )的变化。 方法 :将 10 0例患者分设软坚清脉方组 5 0例 (85肢 )、丹参对照组 4 0例 (71肢 )、多烯康对照组 10例 (16肢 ) ,分别对患肢进行TcpO2 进行临床疗效动态对比研究。结果 :三组患者膝以下部位TcpO2 下降 ,氧弥散及微循环明显障碍。 4周时 ,各组治疗前后及组间比较 ,无明显差异 ;12周时软坚清脉方组治疗前后于患肢远端TcpO2 差异显著 (P <0 0 1) ,且优于两对照组 (P <0 0 1)。延长治疗 2 4周时软坚清脉方组仍显示较好的优势 (P <0 0 1) ,且对缺血严重部位疗效突出。 结论 :软坚清脉方有明显改善缺血肢体经皮氧分压作用 ;延长服药时间 ,则疗效更稳定。
Objective To observe the clinical effect on transcutaneous oxygen tension(TcpO 2)in atherosclerotic occlusion(ASO) treated with prescription of Tuanjianqingmai(RJQM) Methods One hundred patients with ASO were randomly divided into 50 patients(85 limbs) of RJQM group,red root group 40 patients(71 limbs) and ethyl polyenoate soft group 10 patients(16 limbs);and dynamic studies of TcpO 2 were performed at different points in patient's limbs.Results the TcpO 2 showed a decrease and reduction of oxygen diffusion with microcirculatory disturbance in distal to knee region of the three pre treatment groups.At W4 the TcpO 2 had a little increase in the RJQM group,with no significant difference between untreated and treated cases and compared with the two control groups.At W12,the levels of TcpO 2 of RJQM group had a significant difference from the pre and post treatment on distal limbs points( P <0 01),and were favorable than those in the control groups. Conclusion The prescription of RJQM can effectively improve TcpO 2 levels of ischemia of extremity end,and prolongation of medicine administration may significantly improve the clinical effect.
出处
《中国中西医结合外科杂志》
CAS
2004年第5期343-345,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
国家科技攻关项目 ( 85 -919-0 3 -0 1)
