摘要
目的 对谷胱甘肽-S-转移酶M1(GSTM1)基因多态与食管癌的关联性进行Meta分析。方法 以食管癌组与对照组人群基因型分布的OR值为效应指标,各资料间进行一致性检验,以确定采用固定或随机效应模型进行合并分析。发表偏倚评估用漏斗图法进行。结果 共收集国内外相关资料11篇,积累病例1190例,对照1964名,合并OR值为1.197(95％CI:0.846～1.692)。对其中5篇资料按吸烟与否分层,吸烟组合并OR值为1.523(95％CI:1.099～2.109);不吸烟组合并OR值为0.933(95％CI:0.469～1.692)。结论 GSTM1基因多态与食管癌的易感性无关,但携带GSTM1空白基因型的吸烟者患食管癌的危险性可能会增加。
Objective To study the association of genetic polymorphism of glutathione S-transferase M1 (GSTM1) and its susceptibility to esophageal cancer. Methods Odds ratio was employed to evaluate the risk of esophageal cancer and GSTM1 status. To take into account the possibility of heterogeneity across the studies, a statistical test for heterogeneity across the studies was performed. Both fixed and random effect Meta-analysis models were used. Publication bias was evaluated by funnel plot, Results A total of 1190 cases and 1964 controls from 11 studies was included. The pooled OR(with 95% CI)was 1. 197 (0.846-1. 692). Of 11 studies,5 studies were stratified by smoking, In smoking groups, the pooled OR was 1. 523(1. 099- 2. 109) while in non-smoking groups, the pooled OR was 0. 933(0. 469- 1. 692). Conclusion Our results through Meta-analysls did not support the association between GSTM1 null genotype and esophageal cancer, but the smokers carring the GSTM1 null genotype might be associated with the increased risk of esophageal cancer.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2004年第10期898-901,共4页
Chinese Journal of Epidemiology
