肿瘤治疗的新靶点HIF-1
被引量:2
HIF-1:a new target for cancer treatment
出处
《中国现代普通外科进展》
CAS
2004年第5期265-266,269,共3页
Chinese Journal of Current Advances in General Surgery
基金
教育部博士点专项科研基金资助项目 ( 2 0 0 2 0 42 2 0 42 )
国家自然科学基金资助项目 ( 3 0 3 0 0 12 4)
参考文献17
-
1O'Rourke JF,Tian PJ,Ratcliffe PJ,et al.Oxygen-regulated and transactivating domains in endothelial PAS protein1:Comparison with hypoxia-inducible-factor-la[J].J Biol Chem,1999,274:2060-2071.
-
2Zelzer E,Levy Y,Kahana C,et al.Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1a/ARNT[J].EMBO J,1998,17:5085-5094.
-
3Richard DE,Berra E,Gothie E,et al.P42/P44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor la(HIF-1a) and enhance the transcriptional activity of HIF-1[J].J Biol Chem,1999,274:32631-32637.
-
4Mircea I,Keiichi K,Haifeng Yang,et al.HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation:Implications for O2 Sensing[J].Science,2001,292(5516):464-468.
-
5Sonja AD,Maria MY,Roberto NP,et al.Structural basis for Hif-1a/CBP recognition in the cellular hypoxic response[J].Natl Acad Sci USA,2002,99(8):5271-5276.
-
6Mahon PC,Hirota K,Semenza GL,et al.FIH-1:a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity[J].Genes Dev,2001,15(20):2675-2686.[7]Rajani R,Bijoyesh M,Zaver M,et al.Regualtion of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor la[J].Genes Dev,2000,14(1):34-44.
-
7Zhong H,Chiles K,Feldser D,et al.Modulation of hypoxia-inducible factor lalpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells:implications for tumor angiogenesis and therapeutics[J].Cancer Res,2000,60(6):1541-1545.
-
8Chun NL,Prem P.Identification of a Hypoxia Response Element in the Transferrin Receptor Gene[J].J Biol Chem,1999,274(34):24147-24152.
-
9Kurokawa T,Miyamoto M,Kato K,et al.Overexpression of hypoxia-inducible -factor lalpha(HIF-1alpha)in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage[J].Br J Cancer,2003,89(6):1042-1047.
-
10Katrina MC,Timothy JW,Jrn K,et al.Hypoxia-inducible factor-1-dependent regulation of the multidrug resistence(MDR1)gene[J].Cancer Res,2002,62:3387-3394.
同被引文献33
-
1朱虹,陈孝平,罗顺峰,关剑,张万广,张必翔,王海平.缺氧诱导因子1α依赖性缺氧诱导人肝癌细胞多药耐药相关基因的表达及意义[J].中华外科杂志,2005,43(5):277-281. 被引量:27
-
2裘正军,蒋奕,胡文慧,孙红成.HIF-1α、VEGF在胰腺癌组织中的表达及其与血管新生的关系[J].肿瘤,2005,25(2):155-157. 被引量:10
-
3李晓峰,陈仕平.以缺氧诱导因子-1为靶点的肿瘤治疗展望[J].福建医药杂志,2005,27(2):156-158. 被引量:2
-
4黄铄,王永来,陈英汉,刘丽红,聂小毳.低氧诱导因子1α在子宫内膜癌组织中的表达及其与肿瘤血管生成的关系[J].中华妇产科杂志,2005,40(11):785-786. 被引量:2
-
5高洁,代志军,王西京,郭新宁.缺氧诱导因子-1与肿瘤发生发展的关系[J].现代肿瘤医学,2007,15(2):273-275. 被引量:6
-
6[3]BOS R,VAN DER GROEP P,GREIJER AE,et al.Levels of hypoxia-inducible factors 1 alpha independently predict prognosis in patients with lymph node negative breast carcinoma[J].Cancer,2003,97(6):1573-1581.
-
7[5]SIVRIDIS E,GIATROMANOLAKI A,GATTER KC,et al.Association of hypoxia-inducible factors 1 alpha and 2 alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma[J].Cancer,2002,95(5):1005-1063.
-
8[7]STOELTZING O,LIU WB,REINMUTH N,et al.Regulation of hypoxia-inducible factors-1,vascular endothelial growth factor,and angiogenesis by an insulin-like growth factor-1 receptor antocrine loop in human pancreatic cancer[J].Am J Pathol,2003,163(3):1001-1011.
-
9Semenza GL, Wang GL. Anuclear factor induced by hypoxia via denovo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation [J]. Mol CellBiol, 1992, 12 (12) : 5447-5454.
-
10Fyles A, Milosevic M, Hedley D, et al. Tumor hypoxia has inde- pendent predictor impact only in patients with node-negative cervix canced [J]. J Clin On col, 2002, 20 ( 3 ) : 680-687.
引证文献2
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1刘丽丽,战雪梅,孙崇伟.HIF-1α和TopoⅡ在子宫内膜癌中的表达及意义[J].山东医学高等专科学校学报,2008,30(2):81-83.
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2张静雯,常福厚,白图雅,姜雪燕,周枫叶.HIF-1在肿瘤形成中的作用及以其为靶标进行抗肿瘤药物研究的进展[J].中南药学,2013,11(11):821-823. 被引量:1
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1沈红,崔进,秦湧,朱祎娜,蔡健康.晚期非小细胞肺癌患者化疗前后血清HIF-1α和VEGF的变化及临床意义[J].现代肿瘤医学,2015,23(6):791-794. 被引量:8
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2闫哲,白立立,赵伟静,张洪珍.HIF-1α E-cadherin在乳腺中的表达及意义[J].河北医学,2015,21(6):914-917. 被引量:3
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3李娜,高社干.HIF-1在食管癌中的表达及临床意义[J].中外医疗,2014,33(10):80-81.
-
4王丽君,胡春燕,牟蔚琦.肺癌放疗的护理[J].实用肿瘤学杂志,2006,20(4):330-330. 被引量:1
-
5王国开,杨学军.缺氧诱导因子-1α在胶质瘤中的研究进展[J].国际神经病学神经外科学杂志,2006,33(1):47-51. 被引量:2
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6施红旗,翟晓利,刘庆伟.缺氧诱导因子-1α、血管内皮生长因子在前列腺癌中的表达及意义[J].实用肿瘤学杂志,2007,21(3):265-267. 被引量:2
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7刘海燕,沈雷,张鹏,李静平,纪亮.缺氧诱导因子-1α在胃腺癌的表达及临床意义[J].重庆医科大学学报,2011,36(6):657-659.
-
8景绍武,王雅棣.缺氧诱导因子-1与肿瘤[J].癌变.畸变.突变,2011,23(3):235-237. 被引量:6
-
9黄江波,陈兰林,申鹏飞.缺氧诱导因子-1在泌尿系肿瘤中的研究进展[J].医学临床研究,2005,22(8):1157-1160.
-
10何凯,王慧香,张桂荣,苏丽,谭秀梅,杜绍敏,张雪芹.HIF-1α、VEGF在外阴鳞状细胞癌中的表达与临床意义[J].中国妇幼保健,2008,23(14):2005-2006.