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肿瘤治疗的新靶点HIF-1 被引量:2

HIF-1:a new target for cancer treatment
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作者 喻芳 周庚寅
出处 《中国现代普通外科进展》 CAS 2004年第5期265-266,269,共3页 Chinese Journal of Current Advances in General Surgery
基金 教育部博士点专项科研基金资助项目 ( 2 0 0 2 0 42 2 0 42 ) 国家自然科学基金资助项目 ( 3 0 3 0 0 12 4)
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  • 2Zelzer E,Levy Y,Kahana C,et al.Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1a/ARNT[J].EMBO J,1998,17:5085-5094.
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  • 6Mahon PC,Hirota K,Semenza GL,et al.FIH-1:a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity[J].Genes Dev,2001,15(20):2675-2686.[7]Rajani R,Bijoyesh M,Zaver M,et al.Regualtion of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor la[J].Genes Dev,2000,14(1):34-44.
  • 7Zhong H,Chiles K,Feldser D,et al.Modulation of hypoxia-inducible factor lalpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells:implications for tumor angiogenesis and therapeutics[J].Cancer Res,2000,60(6):1541-1545.
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  • 9Kurokawa T,Miyamoto M,Kato K,et al.Overexpression of hypoxia-inducible -factor lalpha(HIF-1alpha)in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage[J].Br J Cancer,2003,89(6):1042-1047.
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