环氧合酶-2与胆管癌

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摘要环氧合酶是花生四烯酸代谢的限速酶 ,有环氧合酶 - 1和环氧合酶 - 2两种异构体 ,其中环氧合酶- 2是一种诱导酶 ,在组织损伤、炎症、肿瘤等情况下表达增强。近年来流行病学、动物实验、体外药理学实验等方面的证据表明环氧合酶 - 2与肿瘤的发生发展密切相关 ,非甾体抗炎药可降低肿瘤的发生。胆管癌是一种胆道常见恶性肿瘤 ,其发生与慢性炎症有关 ,环氧合酶 - 2对胆管癌的发生发展具有促进作用 ,选择性环氧合酶 -

作者孔琦黄强

机构地区安徽医科大学医学二系安徽省立医院普外科安徽省立医院普外科

出处《现代肿瘤医学》 CAS 2004年第5期482-484,共3页 Journal of Modern Oncology

关键词环氧合酶-2 胆管癌非甾体抗炎药

分类号 R735.8 [医药卫生—肿瘤] Q786 [生物学—分子生物学]

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现代肿瘤医学

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环氧合酶-2与胆管癌

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