摘要
目的 探讨乏氧诱导因子 1α(HIF 1α)在非小细胞肺癌中的表达水平及其临床意义。方法 采用免疫组织化学技术检测HIF 1α在 68例非小细胞肺癌标本中的表达。结果 HIF 1α在非小细胞肺癌中的阳性表达率为 5 7.3 5 %( 3 9/ 68)。腺癌中HIF 1α阳性表达率为 5 4.76%( 2 3 / 42 ) ,鳞癌为 61.5 4%( 16/ 2 6) (P>0 .0 5 ) ;中高分化的肿瘤标本中HIF 1α阳性表达率 ( 74.2 9%,2 6/ 3 5 )显著高于低分化的肿瘤标本 3 9.3 9%( 13 / 3 3 ) (P <0 .0 5 ) ;Ⅰ～Ⅱ期HIF 1α的阳性表达率 ( 86.96%,2 0 / 2 3 )显著高于Ⅲ～Ⅳ期 42 .2 2 %( 19/ 45 ) (P<0 .0 5 )。HIF 1α的表达与患者性别、年龄及有无淋巴结转移无明显关系。结论 HIF 1α在非小细胞肺癌中有着较高的表达率 ,且与肿瘤的分化程度和临床分期有一定的关系 ,提示在非小细胞肺癌的治疗中应该重视HIF
Objective To explore the expression level and its clinical significance of hypoxia inducible factor 1α (HIF 1α) in non small cell lung cancer. Methods The expression of HIF 1α was detected in 68 human non small cell lung cancer samples by immunohistochemistry. Results Thirty nine (57.35%) out of 68 human non small cell lung cancer samples were positive for HIF 1α. The positive rate of HIF 1α in adenocarcinoma was 54.76% (23/42) and 61.54% (16/26) in squamous cell carcinoma ( P >0.05) respectively. The positive rate of HIF 1α in moderate to well differentiated samples was 74.29%(26/35) and 39.39%(13/33) in low differentiated samples respectively ( P <0.05). The expression rate of HIF 1α in Ⅰ Ⅱ stage ( 86.96%, 20/23) was significantly higher than that in Ⅲ Ⅳ stage (42.22%,19/45)( P <0.05). The positive expression of HIF 1α was not related to sex and age of patients and lymph node status. Conclusion High expression of HIF 1α exists in non small cell lung cancer, and it may be related to cell differentiation and TNM stage of tumor. The results suggest that resistance to radiotherapy and chemotherapy induced by HIF 1α should be considered in the treatment of non small cell lung cancer.
出处
《中国肺癌杂志》
CAS
2004年第4期344-346,共3页
Chinese Journal of Lung Cancer
关键词
非小细胞肺癌
乏氧诱导因子-1Α
Non-small cell lung cancer Hypoxia inducible factor 1α
