摘要
目的:探讨脑缺血损伤对突触的影响。方法:采用大鼠,制成脑缺血模型,应用透射电镜观察大脑顶叶皮质突触的变化。结果:随着缺血时间的延长,神经毡内突触数目逐渐减少;突触结构中突触小泡、线粒体也发生改变。缺血48 h,突触小泡减少,甚至消失;线粒体变性、减少乃至消失,嵴减少或消失呈空泡状。突触前后膜被破坏,典型的突触结构已不存在。结论:脑缺血后,随缺血时间延长,突触结构异常,突触密度下降。
Objective : To study the relationship between cerebral ischemia and synapse, looking for a new method for studying the brain plasticity after cerebral ischemia. Methods : Cerebral ischemia was induced by permanently occluding the distal middle cerebral artery in healthy SD rats, and electronic microscope was used. Results : After cerebral ischemi-a, the number of the synaptic terminals decreased and the synaptic structure was damaged; the amount of synaptic vesicles were decreased; the cristae of mitochondria were broken, dissolved and disappeared. Presynaptic and postsynaptic membrane became unclear; the outline of presynaptic element was irregular. Fourty-eight hours after ischemia, synaptic vesicles decreased so much that some disappeared. The mitochondria had vacuolar degeneration and sometimes disappeared. The presynaptic and postsynaptic membrane were damaged so seriously that the typical synaptic structure did not exist. Conclusion : After cerebral ischemia, the number of the synaptic terminals decrease and the synaptic structure are dam-
出处
《解剖学杂志》
CAS
CSCD
北大核心
2003年第6期587-590,共4页
Chinese Journal of Anatomy
