摘要
目的 探讨吸烟、饮茶、饮酒与阿尔茨海默病 (AD)是否存在病因联系。方法 以人群为基础 ,将 4 0 2例AD患者纳入病例组 ,384名健康老年人纳入对照组 ,以年龄、性别、受教育程度为匹配条件 ,进行m∶n配对的病例对照研究 ,条件Logistic模型进行单因素和多因素分析。吸烟和血管事件之间进行交互分析。结果 经多因素分析发现 ,5 0岁以上每月饮茶 1～ 3次者在AD组中的比例低于其在正常对照组中的比例 [OR(OddsRatio) =0 75 7,P =0 0 0 0 1],随着饮茶频率的增加 ,OR值减少。几乎每天饮茶者OR值为 0 4 338。 5 0岁以上吸烟量为 0 1～ 9 9包 年在AD组中的比例低于其在健康对照组中的比例 (OR =0 76 9,P =0 0 6 0 2 ) ,吸烟量≥ 10包 年者的OR值为 0 5 914。吸烟和血管事件之间存在反向交互作用。未发现饮酒与AD有关联。结论 饮茶可能是AD的保护因素 ,吸烟本身可能对AD具有保护作用 ,另外可能通过血管事件增加患AD的危险。饮茶、吸烟对AD的保护作用存在剂量 效应关系。本研究为在人群中预防和治疗AD提供了有益的线索。
Objectives To investigate the risk of Alzheimer's disease (AD) associated with smoking,tea-drinking and alcohol-drinking.Methods We conducted a population based,m∶n matched case-control study on 402 AD patients,and 384 controls matched for age,sex and education. Univariate and multivariate analysis was conducted using conditional Logistic model. Cross analysis was conducted between smoking and vascular events.Results In multivariate analysis ,the OR (odds ratio) was 0.757 for individuals over 50 years old regular tea drinking 1-3 times per month compared with those less than once per month( P =0.0001). And the OR for AD decreased as the frequency of tea-drinking was increased. The OR was 0.4338 for those who drink tea almost everyday. Compared with those who didn't smoke over 50 years old,the OR was 0.769 for 0.1～9.9 pack-year smokers( P =0.0602).While the OR for those who smoked over 10 pack-year was 0.5914 . There were negative cross effects between smoking and vascular events. There was no relation between alcohol-drinking and AD. Conclusion This preliminary case-control study suggests that the regular tea-drinking may be the protective factors of AD. Smoking might reduce the risk of AD by itself and increase the risk of AD through the effect of vascular events. There should be dose-response association between regular tea-drinking or smoking and AD. The study might also benefit to the therapy and prevention of AD.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2004年第3期234-238,共5页
Chinese Journal of Neurology
关键词
吸烟
饮茶
饮酒
阿尔茨海默病
病例对照研究
Alzheimer disease
Smoking
Alcohol-drinking
Tea-drinking
Case-control studies
