摘要
目的研究阿尔茨海默病(AD)与血清维生素B12、叶酸及血浆同型半胱氨酸水平之间的关系。方法采用简易精神状态量表(MMSE)对30例AD患者和30例同龄健康人进行评分,并用放射免疫分析法测定血清维生素B12及叶酸水平;用荧光偏振免疫法测定血浆同型半胱氨酸。结果AD组维生素B12水平为(217.3±134.2)pmol/L明显低于对照组(313.6±184.7)pmol/L,两者差异有极显著性(P<0.001)。AD组血浆同型半胱氨酸为(18.9±6.8)μmol/L高于对照组(9.4±4.1)μmol/L,差异有极显著性(P<0.001)。AD组叶酸水平为(29.2±12.7)nmol/L低于对照组(37.2±21.2)nmol/L,但差异无显著性(P>0.05)。AD患者血清维生素B12水平与MMSE得分呈正相关(r=0.87,P<0.01)。结论AD患者血浆维生素B12水平与智能障碍及其程度有关。
ObjectiveTo study the correlation between Alzheimer's disease(AD)and serum vitamin B12,folate,and plasma homocysteine.MethodsThe levels of serum vitamin B12and folate in30AD patients and30healthy subjects were examined using radioimmunoassay.Plasma homocysteine was measured using fluore-scence polarization immunoassay.The mental state was scored using Mini-mental state examination(MMSE).ResultsThe serum vitamin B12[(217.3±134.2)pmol/L]in AD was significantly lower than that of normal controls[(313.6±184.7)pmol/L](P<0.001).The plasma homocysteine in AD[(18.9±6.8)μmol/L]was significantly higher than that of normal controls[(9.4±4.1)μmol/L](P<0.001).The serum folate in AD[(29.2±12.7)nmol/L]was lower than that in normal controls[(37.2±21.2)nmol/L]but without statistical significance(P>0.05).Correlation existed between serum vitamin B12and MMSE scores.ConclusionsSerum vitamin B12level may be related with AD and its severity.
出处
《中国临床营养杂志》
2004年第3期190-192,共3页
Chinese Journal of Clinical Nutrition
