摘要
目的 探讨心力衰竭患儿血浆血管活性肠肽 (vasoactiveintestinalpeptide,VIP)的变化及其临床意义。方法 心力衰竭患儿 4 0例 ,男 2 3例 ,女 17例 ,年龄 0 5～ 7 8岁 ,平均 (3 2± 2 4 )岁。其中心功能Ⅰ级 15例 ,心功能Ⅱ～Ⅳ级 2 5例。应用放射免疫法测定患儿血浆VIP水平 ,以年龄性别相匹配且无心力衰竭的健康体检者 2 3例作为正常对照。结果 心力衰竭患儿血浆VIP(4 3 2 2± 5 4 8)ng/L明显高于正常组 (32 2 4± 4 4 6 )ng/L(P <0 0 5 ) ,应用洋地黄治疗 ,心功能控制后血浆VIP水平 (34 78± 5 4 3)ng/L ,较治疗前明显下降 (P <0 0 5 )。结论 心力衰竭患儿血浆VIP水平明显升高 ,参与心力衰竭的病理生理过程。
Objective To investigate the changes in blood vasoactive intestinal peptide(VIP) in congestive heart failure and it's clinical significance.Methods The level of plasma VIP was measured with radioimmunoassay in 40 patients with congestive heart failure,including Ⅰ degree cardiac function in 15 patients,Ⅱ～Ⅳ degree cardiac function in 25,and 23 normal children who were served as controls.Results In congestive heart failure the level of plasma VIP increased more than those in normal control group [(43.22±5.48)ng/L vs (32.24±4.46)ng/L](P<0.05).After congestive heart failure was controlled with Digitalis ,the level of plasma VIP decteased [(34.78±5.43)ng/L vs (43.22±5.48)ng/L](P<0.05).Conclusion The level of plasma VIP increased in children with congestive heart failure,involving in the pathophysiological process.
出处
《广西医学》
CAS
2004年第9期1256-1257,共2页
Guangxi Medical Journal
基金
广西自然科学基金资助项目 (桂科基 0 1 4 4 0 1 8)
关键词
血管活性肠肽
心力衰竭
放射免疫
Vasoactive intestinal peptide
Heart failure
Immunoradio
