摘要
目的 观察老年性痴呆患者脑CT与听觉认知电位P3 0 0的变化 ,探讨对老年性痴呆进行综合评价的有效方法。方法 采用脑CT和听觉认知电位P3 0 0检查 ,结合神经心理学测试 ,对 3 0例老年性痴呆患者进行测试。结果 听觉认知电位检查发现患者的P3 0 0潜伏期明显延长 ,波幅显著降低 ;CT测量外侧裂宽度和额角指数明显升高 ,反映了以额颞叶为主的脑萎缩。诱发电位和脑CT检查结果均与患者的痴呆程度呈显著性相关。结论 利用脑CT和听觉认知电位P3 0 0 ,结合简易精神状态检查 (MMSE)量表 ,可从形态、功能和神经心理学角度对老年性痴呆患者作出确切评价 。
Objective To observe the changes of cerebral CT and auditory event related potentials (ERP, P300) for finding the effective method for the comprehensive evaluation of the patients with Alzheimer's disease. Methods Cerebral CT, P300, and Mini Mental State Examination (MMSE) were employed to assess 30 patients with Alzheimer's disease. Results Latency and amplitude of wave of P300 in patients were prolonged and decreased, respectively. Cerebral CT found an obvious atrophy in the frontal and temporal lobes of cerebra. These changes were obviously correlated with the severity of dementia. Conclusion Using cerebral CT, P300, and MMSE can offer morphometric, functional and psychological information which is helpful for precise assessment of patients with Alzheimer's disease.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2004年第17期1533-1535,共3页
Journal of Third Military Medical University
基金
重庆市科委科研基金资助项目 ( 56 57)~~
