摘要
①目的 观察高尿酸血症病人血浆纤溶酶原激活物抑制剂 1 (PAI 1 )与内皮素 (ET)水平变化 ,探讨高尿酸血症对血管内皮细胞功能的影响。②方法 选择年龄 >35岁的男性高尿酸血症病人 1 38例为高尿酸血症组 (HUA组 ) ,其中单纯高尿酸血症病人 4 2例为HUA 1组 ,高尿酸并高脂血症或糖耐量异常病人 96例为HUA 2组 ,选择年龄、地域相匹配的健康体检者 4 0例为正常对照组。测定各组血浆PAI 1与ET水平及血清尿酸 (UA)、总胆固醇 (TC)、三酰甘油 (TG)、高密度脂蛋白胆固醇 (HDL C)、低密度脂蛋白胆固醇 (LDL C)、空腹血糖 (FPG)及餐后 2h血糖 (2hPG)、空腹胰岛素 (FINS)、尿素氮 (BUN)及肌酐 (Cr)含量。③结果 HUA、HUA 1、HUA 2组血浆PAI 1与ET水平明显高于正常对照组 (t =1 4 .71～ 33.85 ,P <0 .0 1 ) ,HUA 2组的PAI 1、ET水平明显高于HUA 1组 (t =2 .4 1、2 .1 7,P <0 .0 5 )。在以UA为因变量的多元逐步回归分析中 ,TG、LDL C、BUN、Cr、PAI 1、ET进入方程 (R2 =0 .4 3,P <0 .0 0 1 )。④结论 高尿酸血症与血管内皮细胞损伤关系密切 。
Objective To study the variation of plasminogen activator inhabitor 1 (PAI 1) and endothelin (ET) in patients with hyperuricemia, and evaluate the effects of hyperuricemia on the function of vascular endothelial cells. Methods Of 138 male patients, over 35 years old, who had hyperuricemia were selected as hyperuricemia group (HUA Group), in which, 42 with simple hyperuricemia served as HUA 1 Group ,and 96 accompanying with hyperlipidaemia or impaired glucose tolerance as Group HUA 2. Forty healthy persons with same age and in same area were recruited as control group. Plasma PAI 1 and ET, and serum uric acid, total cholesterol, triglyceride(TG), high density lipoprotein cholesterol(HDL C), low density lipoprotein cholesterol(LDL C), fasting and 2 h postprandial blood sugar, fasting blood insulin, blood urea nitrogen(BUN) and creatinine(Cr) were measured for each group. Results PAI 1 and ET levels in groups HUA,HUA 1 and HUA 2 were notably higher than those in the control group ( t=14.71-33.85,P <0.01). PAI 1 and ET levels in group HUA 2 were apparently higher than group HUA 1 ( t=2.41,2.17;P <0.05). A multiple regression analysis revealed that TG,LDL C,BUN,Cr,PAI 1 and ET levels contributed to the UA levels ( R 2=0.43 ,P <0.001). Conclusion A close relationship exists between hyperuricemia and damage of vascular endothelial cells, the damage aggravates when accompanying disorder of glucolipid metabolism.
出处
《青岛大学医学院学报》
CAS
2004年第3期216-218,共3页
Acta Academiae Medicinae Qingdao Universitatis
