摘要
目的 评价乳泉冲剂对实验性泌乳不足大鼠泌乳量的影响。方法 取Wistar大鼠 ,随机分为 6组 ,选用己烯雌酚建立实验性泌乳不足模型。各组母鼠自产后当天起 ,每日给药一次 ,连续 10d ,记录母鼠的泌乳量 ,用放射免疫法测定母鼠血清催乳素 (PRL)水平 ,并取乳腺活检。结果 乳泉冲剂可使母鼠泌乳量明显增多 ,仔鼠体重增长加速 ,且母鼠的血清催乳素分泌水平有所提高。
OBJECTIVE To estimate the effects of Ruquan granules on milk production in rats with experimental defective lactation. METHOD Wistar rats were randomly divided into 6 groups, diethylstilbestrol was used to create the insufficient lactation model. Ruquan granules were administered once a day for 10 days after postpartum. The lactation amount, serum prolation content and the morphology of mammary gland were determined.RESULTS Ruquan granules increased significantly the lactation amount of breast feeding rats and average weights of newborn rats. Meanwhile, serum prolactin contents in the rat models with lactation insufficiency induced by diethylstilbestrol were elevated at some degree. CONCLUSION Ruquan granules can effectively antagonized the lactation inhibiting effect of diethylstilbestrol.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2004年第4期324-326,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
乳泉冲剂
泌乳量
催乳素
Ruquan granule
the lactation amount
prolation
