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泌尿系肿瘤多药耐药的研究进展

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摘要 多药耐药 (MDR)是导致临床化疗失败的重要原因 ,对MDR及其逆转药的研究成为克服肿瘤耐药和提高化疗疗效的关键所在。泌尿系常见肿瘤MDR的形成机制复杂 ,可能与P 糖蛋白 (P gp)、多药耐药相关蛋白 (MRP)等过度表达、凋亡基因的缺失或抗凋亡基因的过度表达等有关。逆转药有P gp抑制药、细胞因子等。
作者 张炜 张杰
出处 《医药导报》 CAS 2004年第9期637-640,共4页 Herald of Medicine
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