摘要
目的 :探讨血浆高敏感 C反应蛋白 (hs- CRP)和淀粉样物质 A(SAA)与冠状动脉病变程度和病变活动性之间的关系。 方法 :分析 94例冠状动脉造影患者的临床资料 ,并采用乳胶增强速率散射比浊法测定患者循环血中 hs- CRP与 SAA水平。 结果 :临床诊断急性冠状动脉综合征患者血浆 hs- CRP和 SAA水平为 (1 6 .34± 1 6 .0 2 )和 (9.4 6± 6 .97) mg/ L ,明显高于正常对照组的 (1 .0 7± 1 .1 2 )和 (1 .2 4± 1 .1 1 ) m g/ L (P<0 .0 1 ) ;稳定型心绞痛组为 (2 .76± 2 .31 )和 (2 .85± 2 .1 3) mg/ L ,与对照组间无显著性差异 ;中、重度病变 ,单支、双支、三支病变及 Gensini积分 2 1～ 4 0分者 hs- CRP和 SAA水平明显高于对照组(P<0 .0 5 ,P<0 .0 1 )。结论 :冠心病的发生、发展过程中存在炎症反应 ;血浆 hs- CRP和 SAA水平可作为炎症标志物反映冠状动脉炎症状况 。
Objective:To study the relationship among high-sensitivity C-reactive protein,serum amyloid A and the severity of coronary lesions.Methods:We studied the data of coronary angiography in94patients and measured their plasma concentrations of high-sensitivity C-reactive protein(hs-CRP)and serum amyloid A with an immunophelometric assay.Re-sults:Plasma concentrations of hs-CRP and serum amyloid A were significantly raised in acute coronary syndrome [(16.34±16.02)mg/L and(9.46±6.97)mg/L]compared with stable angina pectoris group [(2.76±2.31)mg/L and(2.85±2.13) mg/L](P<0.01)and normal controls [(1.07±1.12)mg/L and(1.24±1.11)mg/L](P<0.01).There was no signifi-cant difference between the latter2groups.Plasma concentrations of hs-CRP and serum amyloid A were significantly higher in patients with moderate to severe lesions,with single,double and3branches lesions,and with Gensini score being21-40than those in control groups(P<0.05,P<0.01).Conclusion:Inflammation is associated with coronary artery disease pro-gression.The levels of hs-CRP and serum amyloid A may reflect inflammatory activity of atherosclerotic diseases,which has diagnosis value for the acute coronary syndrome.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2004年第7期763-765,共3页
Academic Journal of Second Military Medical University
关键词
冠状动脉疾病
炎症
高敏感C反应蛋白
淀粉样物质A
coronary disease
inflammation
high-sensitivity C-reactive protein
serum amyloid A
