摘要
五年来作了膈肌功能研究,包括正常人和COPD患者吸气肌强度和耐力与肺功能的关系;最大自主通气对膈肌肌电图的变化,动物实验犬RDS膈肌功能的变化及氨茶碱疗效的观察;犬缺氧及二氧化碳潴留模型的膈肌肌电图及跨膈压测定及刺激频率对膈肌疲劳的影响。证明在RDS犬及缺氧,二氧化碳潴留以及COPD患者存在膈肌疲劳现象。氨茶碱,西地兰及β_2受体兴奋剂舒喘宁对膈肌疲劳有减轻和预防作用。
The study on the functions of the diaphragm has been carried on for 5 years.It consisted of the studies on the relationship of the tension and endurance of inspiratory muscles with pulmonary functions,the changes of diaphragmatic electromyogram in maximal ventilation volume test in normal subjects and patients with chronic obstructive pulmonary disease(COPD),the functional changes of the diaphragm in dogs with RDS and the therapeutic effects of aminophylline.the changes of diaphragmatic electromyogram in dogs with hypoxemia and hy-percapnia,determination of transdiaphragmatic pressure,the relationship of the stimulation frequency on the phrenic nerve with diaphragmtic fatigue,etc.It was found that there existed di-aphragmtic fatigue in dogs with RDS,in dogs with hypoxemia and hypercapnia,and in patients with COPD,and aminophylline,digoxin,salbutomal β-receptor excitory agents can minimize or prevent diaphragmatic fatigue.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1993年第2期126-131,共6页
Journal of Third Military Medical University
基金
国家自然科学基金
关键词
呼吸窘迫
综合征
膈
氨茶碱
肺功能
reapiratory distress syndrome
diaphragm
digoxin
albuterol
aminophylline
pulmonary function
transdiaphragmtic pressure
diaphragmatic electromyogram
