摘要
目的 :通过正交设计试验筛选出制备环丙沙星聚乳酸微球的最佳工艺。方法 :用正交试验设计优化环丙沙星聚乳酸微球制备工艺 ,用电子显微镜观察微球表面形态 ,差示扫描热分析确证含药微球的形成 ,及对微球的平均粒径、粒度分布、载药量、包封率、工艺重现性进行了研究。结果 :环丙沙星聚乳酸微球的形态圆整 ,且药物确已被包裹在微球中 ,微球的平均粒径为 2 80 .80± 0 .15 μm ,粒径在 2 5 0～ 390 μm左右的占总数的 90 %以上 ,载药量为 (34.1± 0 .5 1) % ,包封率为 (6 8.5± 0 .5 8) % ,最佳工艺条件重现性良好。结论 :本研究获得了制备环丙沙星聚乳酸微球的较满意的工艺。
AIM:To optimize the preparation technology of ciprofloxacin polylactic acid microspheres through orthogonal test. METHOD:The orthogonal test design was used to optimize the technology of preparation. The surface morphology of the microspheres was observed by SEM. The formation of ciprofloxacin microspheres was confirmed by DSC. The mean diameter and the size distribution of microspheres,the drug leading,the incorporation efficiency,the reappearances of pharmaceutical technology were examined. RESULT:The ciprofloxacin polylactic acid microspheres were regular in their morphology. Ciprofloxacin was enveloped in microspheres and not physically mixed with polylactic acid. The average particle size of microspheres was 280.80±0.15 μm with over 90% of the microspheres being in the range of 250～390 μm;the drug loading and the incorporation efficiency were (34.1±0.51)% and (65.7±0.58)% respectively. The reappearance of pharmaceutical technology was good. CONCLUSION: This paper described the optimized preparation technology of ciprofloxacin polylactic acid microspheres.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2004年第3期207-210,共4页
Journal of China Pharmaceutical University
基金
广东省自然科学基金资助课题 (No .980 5 0 4)
关键词
环丙沙星
聚乳酸
微球
制备
Ciprofloxacin
Polylactic acid
Microspheres
Preparation
