摘要
目的 检测抑癌基因PTEN、p2 7及Ki 6 7在涎腺粘液表皮样癌中的表达 ,并探讨其意义。方法 采用免疫组织化学SP法对 31例涎腺粘液表皮样癌的PTEN、p2 7和Ki 6 7表达进行检测 ,并作统计学分析。结果 PTEN、p2 7表达在高分化组粘液表皮样癌的阳性率分别为 88 89%、94 4 4 % ,低分化组分别为 5 3 85 %、4 6 15 % ;Ki 6 7增殖指数在高、低分化组间分别为 (5 18± 2 97) %、(10 38± 3 6 5 ) % ,三者在高低分化组间均有统计学差异 (P <0 0 5 ) ;PTEN和p2 7的表达呈正相关 (rs=0 4 4 5 ,P <0 0 5 ) ,p2 7和Ki 6 7的表达呈负相关 (rs=- 0 4 2 3,P <0 0 5 )。结论 涎腺粘液表皮样癌中 ,PTEN、p2 7和Ki 6
Objective To detect the expression of tumor suppressor gene PTEN、p27 and Ki 67 in salivary gland mucoepidermoid carcinomas and investigate their significance. Methods Immunohistochemistry S P method was used to detect the expression of PTEN?p27 and Ki 67 in 18 cases of well differentiated and 13 ones of poorly differentiated human salivary gland mucoepidermoid carcinomas, and statistical analysis was performed. Results Positive rates of PTEN and p27 expression were 88 89% and 94 44% in well differentiated mucoepidermoid carcinomas, respectively. Positive rates of PTEN and p27 expression were 53 85% and 46 15% in poorly differentiated mucoepidermoid carcinomas, respectively. Proliferation index of Ki 67 was (5 18±2 97)%?(10 38±3 65)% in well differentiated and poorly differentiated mucoepidermoid carcinomas, respectively. Positive rates of PTEN and p27 expression and proliferation index of p27 had statistical difference between well and poorly differentiated mucoepidermoid carcinomas, respectively ( P <0 05); Expression status of PTEN was related to that of p27 ( r s=0 445, P<0 05 ), and there was negative correlationship between p27 and Ki 67 ( r s =-0 423, P<0 05 ).Conclusion Expression status of PTEN?p27 and Ki 67 had a correlation with histological grade in salivary gland mucoepidermoid carcinomas.
出处
《口腔颌面外科杂志》
CAS
2004年第2期104-107,共4页
Journal of Oral and Maxillofacial Surgery
