摘要
目的:探讨产后抑郁症与同型半胱氨酸(homocysteine,Hcy)水平的关系。方法:对43例2012年6月至2014年4月在湖南省妇幼保健院心理门诊就诊的产后1年内抑郁症患者以及在产后抑郁症筛查中怀疑产后抑郁症者,采用爱丁堡产后抑郁量表、汉密尔顿抑郁量表等量表进行评估;以中国精神障碍分类与诊断标准第3版(Chinese Classification of Mental Disorder,the third edition,CCMD-3)中抑郁症的诊断标准进行产后抑郁症的诊断;采用多种抑郁量表及临床表现综合的权重分作为综合评价抑郁症状严重程度的计分;采用化学发光法检测血浆Hcy水平。将31例同时期在同一家医院进行保健检查的产后1年内的心理无异常妇女作为对照。结果:产后抑郁症组的血浆Hcy水平[(10.09±3.59)μmol/L)高于产后正常组血浆Hcy水平[(8.57±1.59)μmol/L,t=12.392,P=0.001]。产后抑郁症患者血浆Hcy水平与抑郁严重程度呈正相关(r=0.231,P<0.05)。结论:产后抑郁症的严重程度与血清Hcy水平有一定的相关性,血浆Hcy水平升高可能是预测产后抑郁症的生物标志物。
Objective: To investigate whether the level of homocysteine in patients with postpartum depression is associated with depression index.Methods: A total of 43 women with postpartum depression or with potential postpartum depression, who visited the psychological clinic of Maternal and Child Health Hospital of Hunan Province from June, 2012 to April, 2014, were enrolled in this study. They were evaluated by the Edinburgh Postnatal Depression Scale and Hamilton Depression Scale. Chinese Classification of Mental Disorder(the third edition) was used for their diagnosis. The depressive index was calculated by Edinburgh Postnatal Depression Scale, Hamilton Depression Scale, and clinical symptom scores, which was used to assess the level of depressive symptoms. The level of homocysteine in serum was detected by chemoluminescent method. Meanwhile, another 31 women, who visited the hospital without postpartum depression, were used as controls to compare with the 43 patients.Results: The homocysteine level in the women with postpartum depression was significantly higher than that in the control group [(10.09±3.59) μmol/L vs(8.57±1.59) μmol/L, t=12.392, P=0.001]. The depression index was positively correlated with the level of homocysteine(r=0.231, P<0.05).Conclusion: The level of serum homocysteine is associated with postpartum depression, suggesting that the level of serum homocysteine might be a risk biomarker for postpartum depression.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2015年第3期311-316,共6页
Journal of Central South University ：Medical Science
基金
湖南省医药卫生科研计划(B2012-108)
湖南省科技计划(2014SK3153)~~
