摘要
动脉粥样硬化(As)是一种由炎症、固有免疫以及脂质浸润等多种因素参与的综合性病变。mi RNA是一类长度约18~24 nt的具有调节功能的非编码RNA,是基因转录后水平的重要调控者,能够调节细胞内的反应与功能。研究表明,mi RNA参与了多种血管疾病的进程,如在As的各个阶段中均有mi RNA的功能异常,其中,mi R-145能够通过调节下游多种靶基因表达,从而影响细胞的增殖、迁移以及细胞表型转变,在As的发生、发展中起着重要作用。
Atherosclerosis is one of the comprehensive diseases which caused by several factors such as inflammation,innate immunity and lipid infiltration. Mi RNA comprise a novel class of endogenous,small RNA of 18 ~ 24 nucleotides that regulate the expression of target gene at posttranscriptional level. Mi RNAs’ dysfunction is involved in all the stages of atherosclerosis. Among these mi RNAs,mi R-145 can affect the proliferation,migration and phenotype transformation of cells and participate in atherosclerosis,through regulating the target gene downstream.
出处
《中国动脉硬化杂志》
CAS
北大核心
2015年第5期522-526,共5页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金资助项目(81170279
81370409)
江苏省六大人才高峰资助项目(WS074)
镇江市心血管病重点实验室资助项目(SS2012002)
