摘要
目的探讨髓过氧化物酶(MPO)与冠状动脉慢血流(CSF)之间的相关性。方法采用校正的TIMI血流帧数(CTFC)将随机入选600例经冠状动脉造影(CAG)确诊无冠状动脉狭窄病变并筛查出冠状动脉慢血流的52例患者作为研究对象,随机选择另外无冠状动脉慢血流的52例患者作为对照组。收集两组患者临床指标并测定血浆髓过氧化物酶及血液生化指标,分析两组之间差异,采用Logistic回归法筛选冠状动脉慢血流的危险因素。结果两组基线值相似;冠状动脉慢血流组血浆髓过氧化物酶浓度明显高于对照组(93.70±37.75μg/L比26.76±6.20μg/L,P<0.001),差异有统计学意义;Logistic回归分析表明血浆髓过氧化物酶水平升高与冠状动脉慢血流有独立相关性(OR=1.23,P=0.001)。结论血浆髓过氧化物酶水平与冠状动脉慢血流发生密切相关,可以作为影响冠状动脉慢血流的重要血液生物化学指标。
Aim To investigate the correlation between myeloperoxidase( MPO) and coronary slow flow( CSF).Methods Through corrected TIMI frame count( CTFC),the randomly selected 600 patients without coronary artery stenosis by coronary angiography( CAG) were screened out of 52 patients of CSF as the study group,the other randomly selected52 patients without CSF as the control group. Plasma levels of MPO and other blood biochemical index were obtained in all participants,and analysis of the difference between the two groups,logistic regression analysis was used to screen the risk factors of CSF. Results Baseline values were similar in two groups; MPO levels of the CSF group were significantly higher than control group( 93. 70 ± 37. 75 μg / L vs 26. 76 ± 6. 20 μg / L,P < 0. 001),the difference was statistically significant; Logistic regression analysis showed that high plasma MPO level was related to CSF( OR = 1. 23,P = 0. 001).Conclusion The plasma MPO level is closely related to CSF,which can be used as an important blood biochemical index to influence CSF.
出处
《中国动脉硬化杂志》
CAS
北大核心
2015年第2期185-187,共3页
Chinese Journal of Arteriosclerosis
