摘要
脆性X综合征（fragile X syndrome，FXS）是最常见的引起智力低下的遗传性疾病之一。针刺作为安全有效的治疗手段，正在广泛应用于FXS的治疗，且获得了可喜疗效，但其治疗机制尚未明确。有关针刺治疗机制的研究现在主要从神经递质改变与突触可塑性两方面入手，且从临床症状及受体表达等多方面观察，GABAA受体与FXS之间存在某种联系。本文将简单总结现有的针刺治疗FXS作用机制，并探讨GABAA作为研究针刺治疗脆性X综合征作用机制靶目标的可行性。
Fragile X syndrome (FXS) is one of the most common hereditary diseases that cause mental retardation. Acupuncture, as a kind of safe and effective therapy, is widely used in treatment of FXS, and has received gratifying efficacy, but its therapeutic mechanism is not clear yet. The studies about therapeutic mechanism of acupuncture now are mainly from two aspects of neurotransmitter changes and synaptic plasticity;further-more, observes from clinical symptoms, receptor expressions or many other aspects, there is a certain relation between GABAA receptor and FXS. This article will simply summarize the existing mechanism of acupuncture for FXS, and investigate the feasibility of regarding GABAA receptor as target for studying the mechanism of acupuncture for fragile X syndrome.
出处
《按摩与康复医学》
2013年第12期7-9,共3页
Chinese Manipulation and Rehabilitation Medicine
