摘要
目的观察丹参川芎嗪注射液在辅助辨治缺血性脑卒中过程中的作用和临床效果。方法选取142例缺血性脑卒中患者,按照随机数字表分为试验组和对照组。对照组(n=71)采用常规治疗;试验组(n=71)在常规治疗的基础上加用丹参川芎嗪注射液进行辅助辨治。分别观察治疗前后2组患者的血液流变学变化、神经功能改善情况和治疗效果并进行统计学分析。结果治疗后,对照组患者血浆黏度1.91±0.35,红细胞压积(49.58±1.04)%;试验组患者血浆黏度1.17±0.28,红细胞压积(38.97±1.31)%,2组差异显著(P<0.05)。治疗前对照组神经功能评分为22.49±1.21,试验组患者治疗前评分为23.18±1.74,2组差别不大。治疗后,对照组评分10.58±0.94,试验组为4.62±2.05,2组差异显著(P<0.05)。对照组治疗后总有效率80.3%;试验组治疗后总有效率88.7%,2组差异显著(P<0.05)。结论丹参川芎嗪注射液辅助辨治缺血性脑卒中疗效确切,患者症状得到有效缓解。
Objective To observe the effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in inauxiliary treatment of ischemic stroke and its clinical efficacy. Methods 142 cases of patients with ischemic stroke, were randomly divided into experimental group and control group. Control group(n=71) were treated with conventional therapy. Test group(n=71) were treated with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of conventional therapy. Hemorheological changes, nerve function improvement and treatment efifcacy in two groups before and after treatment were observed and analyzed. Results After treatment, the plasma viscosity and hematocrit in control group were 1.91±0.35, (49.58±1.04)%; while experimental group were 1.17±0.28, (38.97±1.31)%, the differences between two groups were signiifcant(P<0.05). Before treatment, the neurological function score in control group was 22.49±1.21, while experimental group was 23.18±1.74, there was no signiifcant difference between two groups. After treatment, the neurological function score in control group was 10.58±0.94, while experimental group was 4.62±2.05, the difference was signiifcant(P<0.05). The total effective rate was 80.3%in control group ,while 88.7% in experimental group, the difference was signiifcant(P<0.05). Conclusion The clinical efifcacy of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in auxiliary treatment of ischemic stroke was accurate, and it can alleviate the symptom of patients.
出处
《中国生化药物杂志》
CAS
北大核心
2014年第2期120-121,共2页
Chinese Journal of Biochemical Pharmaceutics
基金
广东省卫生厅中青年医师扶持计划(GW-2009 CNO.021)
关键词
丹参川芎嗪注射液
缺血性脑卒中
临床研究
salviae miltiorrhizae and ligustrazine hydrochloride injection
ischemic stroke
clinical study
