摘要
目的:研究8—MOP、ATRA以及二者联合应用对Mc3细胞bcl-2和P^(53)表达的影响。方法:免疫组织化学染色方法。结果:bcl—2表达分别为:对照组(+);8-MOP组(+);ATRA(-);8—MOP与ATRA联合用药组(+);P^(53)表达分别为:对照组(+);8-MOP组(+);ATRA(+);8—MOP与ATRA联合用药组(+)。结论:①ATRA处理组细胞bcl—2的阳性表达明显下降,可能导致Mc3细胞发生凋亡;②P^(53)的表达无明显变化。
Objective: To study effects of 8 -methoxypsoralen (8 -MOP) combined with all trans retinoic acid (ATRA) or alone on bcl -2 andP53 expression in Mc3 cells. Method: Cell immunohistochemical staining method. Result: bcl -2 could express in controal group, 8 -MOP group and combined group, but could not express in A-TRA group. P53 could express in all ofthe four groups. Conclusion; ATRA maybe decrease the bcl -2 expression and induce the apptosis of Mc3 cells, but the expression of P53 is not effected by both agents.
出处
《西南国防医药》
CAS
1999年第6期328-330,共3页
Medical Journal of National Defending Forces in Southwest China
