摘要
Objective Study the β-asaron under the condition that the bowel each segment of rat and be worth in the diffent medicine density and pH of the absorption dynamics characteristic,as to it's the rat absorbs the part in the body and it absorbs the mechanism to carry on the study,for the further design β-asaron settle release the product to provide the living creature medicine learn the basis.Methods Apply the rat to the body to infuse to flow the bowel absorption experiment investigation and absorption dynamics characteristic;adopt the HPLC method measurement β-asaron is in rat body the bowel absorbs the medicine density within the reflux liquid.Results It absorb the quantity and β-asaron of the medicine in the reflux liquid,the density of β-asaron becomes the direct proption,the absorption speed constant of the medicine is basic and constant within the scope of the 19 μg·mL-1-57 μg·mL-1;In the pH is 5.6;6.9;8.0 three kinds of dissimilarities lie the absorption velocity constant of the quality and absorb the of percentage and also did not show the difference of salience;β-asaron is in the small intestines the lower part absorb better,absorbthe velocity to press to return to bowel,ileum,jejunum,duodenum,colon to descend one by one in order,absorb the velocity constant one by one in order is 0.402,0.396,0.385,0.325 h-1.Conclusions β-asaron absorbs to present a class absorption dynamics characteristic in the bowel way,absorbing the mechanism as passive absorption;in order to return to ileum and jejunums,main absorption part there is certain absorption in the colon,too.
Objective Study the β-asaron under the condition that the bowel each segment of rat and be worth in the diffent medicine density and pH of the absorption dynamics characteristic,as to it's the rat absorbs the part in the body and it absorbs the mechanism to carry on the study,for the further design β-asaron settle release the product to provide the living creature medicine learn the basis.Methods Apply the rat to the body to infuse to flow the bowel absorption experiment investigation and absorption dynamics characteristic;adopt the HPLC method measurement β-asaron is in rat body the bowel absorbs the medicine density within the reflux liquid.Results It absorb the quantity and β-asaron of the medicine in the reflux liquid,the density of β-asaron becomes the direct proption,the absorption speed constant of the medicine is basic and constant within the scope of the 19 μg·mL-1-57 μg·mL-1;In the pH is 5.6;6.9;8.0 three kinds of dissimilarities lie the absorption velocity constant of the quality and absorb the of percentage and also did not show the difference of salience;β-asaron is in the small intestines the lower part absorb better,absorbthe velocity to press to return to bowel,ileum,jejunum,duodenum,colon to descend one by one in order,absorb the velocity constant one by one in order is 0.402,0.396,0.385,0.325 h-1.Conclusions β-asaron absorbs to present a class absorption dynamics characteristic in the bowel way,absorbing the mechanism as passive absorption;in order to return to ileum and jejunums,main absorption part there is certain absorption in the colon,too.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2008年第S1期120-120,共1页
Journal of Shenyang Pharmaceutical University
