摘要
目的:探讨短暂性脑缺血发作(TIA)对后继脑梗死的神经保护作用。方法:选择首发前循环脑梗死患者共208例,根据脑梗死发病前3个月内是否出现有同侧TIA史分为两组:有同侧TIA史的100例为观察组,无TIA史的脑梗死患者108例作为对照组。两组病人入院后均给予相同的治疗方法,检测发病72h梗死灶体积,于治疗前及治疗后20和40天检测神经功能缺损评分及Barthel指数评分。结果:发病72h时观察组患者梗死灶体积显著低于对照组(P<0.05);治疗前及治疗后20和40天,三个不同时间点分别比较,观察组患者神经功能缺损程度评分均低于对照组(P<0.05或P<0.01),观察组患者Barthel指数均高于对照组(P<0.01)。结论:脑梗死前发生的同侧TIA可能产生缺血耐受现象,可减轻随后严重缺血性卒中的神经功能缺损程度,起到神经保护作用。
Objective To evaluate the subsequent neuroprotective effect of transient ischemic attack on follow-up cerebral infarction.Methods Select starting anterior circulation stroke in patients with a total of 208 cases,divided into two groups according to whether there is a history of ipsilateral TIA before cerebral infarction within 3 months:it was the observation group that had a history of ipsilateral TIA of 100 cases,it was the control group that hadn't a history of TIA with cerebral infarction of 108 patients.Two groups of patients were given the same treatment after admission,to detect the incidence 72h infarct size,to detect the neurological deficit score and Barthel index scores before treatment and after treatment of 20 days and 40 days.Results The infarct volume in patients with the observation group were significantly lower than that of the control group at incidence of 72 hours(P<0.05);Before treatment and after treatment 20 and 40 days,respectively,compared three different time points,the score of Neurological deficits in patients with the observation group were lower than that of the control group(P<0.05 or P<0.01),the Barthel index of the observation group were higher than that of the control group(P<0.01).Conclusions It is possible the phenomenon of ischemic tolerance that occurs ipsilateral TIA before cerebral infarction,reduce followed severe ischemic stroke neurological deficits,play a role in neuroprotection.
出处
《中国医学工程》
2009年第12期21-23,共3页
China Medical Engineering
关键词
短暂性脑缺血发作
脑梗死
缺血耐受
神经保护
Transient ischemic attack
Cerebral infarction
Ischemic tolerance
Neuroprotective
