摘要
两亲嵌段共聚物形成的胶束、囊泡等典型的自组装体可作为纳米医药载体,用于药物的控释,其研究已成为当前胶化、医药和生物学科交叉领域的热点。尤其是聚乙二醇型两亲嵌段共聚物,不仅具有良好的生物相容性,而且通过适当的分子设计可形成对环境具有刺激响应的纳米载体。本文着重综述了这类两亲嵌段共聚物的自组装及其在药物控释方面的研究,总结了影响自组装的因素,并介绍了控释药物的机理。
As an excellent self-assembly aggregates, the micelles and vesicles formed by amphiphilic block copolymers could be used as nano-controlled drug delivery system. Especially the copolymers containing PEG chains exhibit excellent biocompatibility, and they will be stimuli-responsive if we design a suitable molecular structure. In this paper, we review the research on self-assembly and drug controlled release of stimuli-responsive amphiphilic block copolymers. Furthermore, we summarize the factors affect the self-assembly of these amphiphilic block copolymers, and we introduce the specific mechanism of the drug-controlled release system.
出处
《胶体与聚合物》
2014年第1期44-48,共5页
Chinese Journal of Colloid & Polymer
基金
国家自然科学基金(51103179)
山东省自然科学基金(ZR2011BL017)
中央高校基本科研业务费
国家留学基金委基金(CSC201206455009)
关键词
两亲高分子
嵌段共聚物
环境响应
自组装
药物控释
amphiphilic polymer
block copolymer
stimuli-responsive
self-assembly
drug controlled release
