摘要
目的观察硫酸亚铁联合美多芭治疗尿毒症不宁腿综合征的疗效。方法根据2003年国际不宁腿综合征委员会(International Restless Legs Syndrome Study Group,IRLSSG)制定的不宁腿综合征(RLS)诊断标准,选取符合诊断标准的尿毒症合并RLS患者65例,随机分成两组,治疗组33例,给予硫酸亚铁联合美多芭治疗;对照组32例,给予美多芭治疗。观察治疗后2、4、12周RLS评分和治疗后2、12周PSG周期性肢动指数、微觉醒指数变化。结果两组治疗前后RLS评分及周期性肢动指数、微觉醒指数均有下降,而且治疗组在治疗后各时间节点上RLS评分及PSG周期性肢动指数、微觉醒指数较治疗前和对照组差异均有统计学意义(P<0.05)。结论硫酸亚铁与美多芭联合应用治疗尿毒症不宁腿综合征有良好疗效,并且在最初两周就有明显治疗效果,效果持续超过三个月。
Objective To investigate the clinical efficacy of ferrous sulfate combined with Madopar on improvement of restless legs syndrome (RLS).Methods Based on the diagnostic criteria of International RLS study group (IRLSSG),65 patients who met the primary diagnostic criteria of RLS were randomly divided into two groups:treatment group (33, ferrous sulfate combined with Madopar) and control group (32,Madopar).The treatment lasted for 12 weeks,and changes of RLS score,periodic limb movement index and arousal index were monitored.Results RLS score changes pre and post treatment were significantly different between two groups. and the result of comparing scores showed remarkable decrease in two groups. However the decrease of the resalt of treatment group is more obvious than that of control group.Conclusion RLS in patients could be improved by the two methods we used and the method of ferrous sulfate combined with Madopar might be more effective.
出处
《河北北方学院学报（自然科学版）》
2014年第2期64-66,71,共4页
Journal of Hebei North University:Natural Science Edition
关键词
硫酸亚铁
美多芭
尿毒症
不宁腿综合症
ferrous sulfate tablets
levodopa and benserazide tablet
uremia
restless legs syndrome
