摘要
BACKGROUND: Fine needle aspiration cytology (FNAC) is a less invasive, inexpensive and rapid method for patho- logic evaluation of hepatic masses. This study was to inves- tigate the role of fine needle aspiration cytology in the early diagnosis of liver disease. METHODS: Fourty-six patients received fine needle ( 1 mm diameter or 18G) aspiration for the diagnosis of liver disease under ultrasonography or computed tomography guidance. The diagnosis was verified by using hematoxylin and eosin (HE) staining and immunohistochemistry. RESULTS: Of the 46 patients, 19 had hepatocellular carci- noma (HCC), 2 cholangiocarcinoma, 1 lymphoma, 1 car- cinoid tumor, 1 squamous cell carcinoma, 1 tuberculosis, 14 no abnormality, and 6 red blood cells. Cytological diag- nosis of 3 patients was inconsistent with histological diagno- sis after surgery: incorrect diagnosis (2), and false-negative for failure of aspiration (1). CONCLUSIONS: Cytological diagnosis should mostly de- pend on cellular morphology. In addition, immunohisto- chemistry and special staining are helpful for diagnosis if cytologic preparation is available. Fine needle aspiration cy- tology of the liver is a diagnostic method that can be used to identify the vast majority of neoplasms of primary or metastatic nature.
BACKGROUND: Fine needle aspiration cytology (FNAC) is a less invasive, inexpensive and rapid method for patho- logic evaluation of hepatic masses. This study was to inves- tigate the role of fine needle aspiration cytology in the early diagnosis of liver disease. METHODS: Fourty-six patients received fine needle ( 1 mm diameter or 18G) aspiration for the diagnosis of liver disease under ultrasonography or computed tomography guidance. The diagnosis was verified by using hematoxylin and eosin (HE) staining and immunohistochemistry. RESULTS: Of the 46 patients, 19 had hepatocellular carci- noma (HCC), 2 cholangiocarcinoma, 1 lymphoma, 1 car- cinoid tumor, 1 squamous cell carcinoma, 1 tuberculosis, 14 no abnormality, and 6 red blood cells. Cytological diag- nosis of 3 patients was inconsistent with histological diagno- sis after surgery: incorrect diagnosis (2), and false-negative for failure of aspiration (1). CONCLUSIONS: Cytological diagnosis should mostly de- pend on cellular morphology. In addition, immunohisto- chemistry and special staining are helpful for diagnosis if cytologic preparation is available. Fine needle aspiration cy- tology of the liver is a diagnostic method that can be used to identify the vast majority of neoplasms of primary or metastatic nature.
