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遗传性静脉血栓栓塞症的研究进展 被引量：4

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摘要 静脉血栓栓塞症(venous thromboembolism,VTE)是一种具有高发病率和死亡率的常见疾病,主要有两种临床表现:深静脉血栓形成(deep vein thrombosis,DVT)和肺动脉栓塞(pulmonary embolism,PE)[1]。在西方国家,原发性DVT的年发病率是(1~3)/1000,其中超过30%的患者在5年内会有至少一次的复发[2]。
作者 方碧晴 张纪蔚
机构地区 上海交通大学医学院附属仁济医院血管外科
出处 《中国血管外科杂志（电子版）》 2014年第1期12-15,共4页 Chinese Journal of Vascular Surgery(Electronic Version)
关键词 遗传性 危险因素 缺陷症 静脉血栓栓塞症 丝氨酸蛋白酶 高凝状态 结构域 基因突变 凝血酶原 凝血因子
分类号 R543.6 [医药卫生—心血管疾病]
  • 相关文献

参考文献11

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  • 2周荣富,王鸿利.遗传性蛋白C缺陷症的研究进展[J].国外医学（输血及血液学分册）,2005,28(3):227-230. 被引量：9
  • 3魏旭倩,王学锋,王鸿利.遗传性抗凝蛋白缺陷症与静脉血栓关系的研究进展[J].国际检验医学杂志,2008,29(2):160-163. 被引量：5
  • 4王鸿利,王学锋.遗传性抗凝因子缺陷症的基因诊断[J].血栓与止血学,2003,9(4):173-175. 被引量：2
  • 5张付华,吴竞生.遗传性抗凝血酶缺乏症研究进展[J].血栓与止血学,2005,11(6):284-286. 被引量：4
  • 6Paolo Bucciarelli,Valerio De Stefano,Serena M. Passamonti,Daniela Tormene,Cristina Legnani,Elena Rossi,Giancarlo Castaman,Paolo Simioni,Michela Cini,Ida Martinelli.Influence of proband’s characteristics on the risk for venous thromboembolism in relatives with factor V Leiden or prothrombin G20210A polymorphisms[J]. Blood . 2013 (15)
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二级参考文献82

  • 1黄斌伦,金佩佩,张浩,余银妹,徐瑞龙,王敏,王学锋,丁秋兰,戴菁,王鸿利.1例遗传性蛋白S缺陷症患者的基因分析[J].中国实验诊断学,2005,9(6):902-903. 被引量：3
  • 2储海燕,诸江,王鸿利,邵慧珍,张庆华,张宇舟,王学锋,杨景文,陈竺,王振义.上海地区深静脉血栓形成患者抗活化的蛋白C及FⅤLeiden突变的初步调查[J].中华血液学杂志,1996,17(9):462-465. 被引量：34
  • 3蔡晓红,周荣富,谢爽,王文斌,戴菁,丁秋兰,方怡,谢飞,王学锋,王鸿利.两个遗传性蛋白C缺陷症家系临床表型和基因型变化的研究[J].中华血液学杂志,2007,28(3):147-151. 被引量：11
  • 4周荣富,蔡晓红,谢爽,王文斌,戴菁,丁秋兰,方怡,谢飞,王学锋,王鸿利.蛋白C基因C64W和F139V突变致蛋白C缺陷的分子机制研究[J].中华血液学杂志,2007,28(3):156-159. 被引量：9
  • 5Lee JJ, Ttiiessen E, Bruley DF. Protein C production: metal ion/ protein interracial interaction in immobilized metal affinity chromatography [J]. Adv Exp Med Biol, 2005, 566 : 381-387.
  • 6Buil A, Soria JM, Souto JC, et al. Protein C levels are regulated by a quantitative trait locus on chromosome 16: results from the Genetic Analysis of Idiopathic Thrombophilia (GAIT) Project [J]. Arterioscler Thromb Vasc Biol, 2004, 24(7) : 1321-1325.
  • 7Medina P, Navarro S, Estelles A, et al. Contribution of polymorphisms in the endothelial protein C reeeptor gene to soluble endothelial protein C receptor and eireulating aetivated protein C levels, and thrombotie risk [J].Thromb Haemost, 2004, 91 (5): 905-911.
  • 8Naito M, Mimuro J, Endo H, et al. Defective sorting to secretory vesieles in.trans-Golgi network is partly responsible for protein C deficiency: molecular mechanisms of impaired secretion of abnormal protein C R169W, R352W, and G376D [J]. Cire Res, 2003, 92(8): 865-872.
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共引文献17

同被引文献66

  • 1张金辉,冯曜宇,金辉.静脉血栓栓塞患者携带LeidenV因子杂合子病例报告[J].中国血管外科杂志（电子版）,2014,6(3):170-174. 被引量：6
  • 2中华医学会血液学分会血栓与止血学组.易栓症诊断中国专家共识(2012年版)[J].中华血液学杂志,2012,33:982.
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引证文献4

二级引证文献29

中国血管外科杂志（电子版）
2014年 第1期

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