摘要
目的观察国产氯吡格雷(泰嘉)在经皮急诊冠状动脉介入治疗患者中应用的疗效。方法以进口氯吡格雷(波立维)为对照组,将248例经临床诊断急性冠脉综合征急诊行PCI术患者随机分为泰嘉组和进口氯吡格雷组,其中泰嘉组124例,进口氯吡格雷组124例,两治疗组PCI术前(至少6小时)口服泰嘉300mg或进口氯吡格雷300mg,以后每日口服泰嘉或进口氯吡格雷75mg/d,维持至少12个月。观察两组PCI术后不良心血管事件及药物不良反应发生率的差异。结果泰嘉和进口氯吡格雷不良心血管事件及药物不良反应发生率均无明显差异。结论泰嘉费用相对低,药物疗效与不良反应发生率与进口氯吡格雷相似,泰嘉可以作为进口氯吡格雷的替代用药,值得推广。
Objective To?observe?the?curative?effect?of?domestic?clopidogrel?(Talcom)?with?PCI?for?the?patients.?Method Using?the?imported?clpidogrel?(Plavix)?as?control?group,?248?cases?who?were?clinically?diagnosed?as?ACS?with?emergency?PCI?were?randomly?divided?into?Talcom?group?and?Plavix?group?with?the?same?numbers.?Both?the?two?groups?took?Tai?Jia?or?Plavix?300mg?orally.at?least?six?hours?before?PCI.?Then?the?patients?took?Talcom?or?Plavix?75mg?orally?everyday?and?lasted?for?12?months?at?least.?Finally,?observed?the?differences?of?the?two?groups?between?the?adverse?cardiovascular?events?and?the?incidence?of?adverse?drug?reactions?after?PCI.?Result There?was?no?obvious?difference?in?adverse?cardiovascular?events?and?the?incidence?of?adverse?drug?reactions?when?using?Talcom?or?Plavix.?Conclusion Talcom?is?cheaper?and?its?curative?effect?and?the?incidence?of?adverse?reaction?are?similar?to?Plavix,?so?it?can?be?used?as?an?alternative?medicine?for?Plavix.?Talcom?is?worthy?of?promotion.
出处
《中国医学前沿杂志（电子版）》
2013年第2期74-77,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
