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膜型凋亡诱导配体脱落可能参与肺腺癌对TRAIL耐受 被引量：1

Shedding of membrane-bound apoptosis inducing ligand may participated drug resistance of lung adenocarcinoma to TRAIL
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摘要 TRAIL可选择性、高效地诱导肿瘤细胞凋亡,虽然肺腺癌等部分肿瘤对TRAIL耐受,但其高效、低毒的优势吸引人们不断探索增敏策略。TRAIL与功能性受体DR4、DR5在细胞膜脂筏内组装为死亡诱导信号复合物(DISC);而诱骗受体DcR1和DcR2通过竞争结合TRAIL阻断凋亡。肺腺癌A549对TRAIL高度耐受,除DcR1外,MMP-2可能通过酶切跨膜型TRAIL的脱落而降低DISC组装,从而参与其耐药。阐明膜结合型TRAIL脱落机制可能为提高肺腺癌对TRAIL的敏感性提供新策略。
作者 李妍 王月华 金宏 陈爽 张慧锋 赵良中 李瑶 李文平 张铎 齐玲 曹慧玲
机构地区 吉林医药学院检验学院 吉林医药学院实验中心 吉林医药学院药学院 吉林医药学院基础医学院 吉林医药学院科研学术处
出处 《吉林医药学院学报》 2013年第1期39-42,共4页 Journal of Jilin Medical University
基金 国家自然科学基金青年基金项目(81202953)
关键词 肿瘤坏死因子相关的凋亡诱导配体 基质金属蛋白酶-2 脂筏 姜黄素
分类号 R541 [医药卫生—心血管疾病]
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参考文献23

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共引文献7

同被引文献5

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  • 5李妍,金伯泉.可溶型细胞因子受体产生机制的研究进展[J].细胞与分子免疫学杂志,2012,28(5):551-553. 被引量：5

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吉林医药学院学报
2013年 第1期

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