期刊文献+

噻托溴铵治疗稳定期慢性阻塞性肺疾病60例肺功能分析 被引量:6

Pulmonary Function Analysis of Using Tiotropium in 60 Patients with Stable Chronic Obstructive Pulmonary Diaease
在线阅读 下载PDF
导出
摘要 目的通过观察患者用药前后肺功能的变化,探讨噻托溴铵治疗稳定期慢性阻塞性肺疾病(COPD)的疗效。方法将60例稳定期COPD患者随机分成实验组和对照组,实验组30例吸入噻托溴铵粉雾剂18μg,每天上午1次;对照组30例口服茶碱缓释片,0.1 g/次,2次/d,治疗疗程4周,测定患者用药前后肺功能的变化。结果两组治疗后肺功能指标均有所改善,实验组较对照组各项指标改善明显(P<0.05)。结论稳定期COPD患者规律吸入噻托溴铵可明显改善肺功能和临床症状。 Objective To evaluate the effect of tiotropium using in Stable Chronic Obstructive Pulmonary Diaease(COPD) through observing the changing of patients' lung function before and after using tiotropium.Methods Dividing 60 patients with stable COPD into 2 groups(experimental group and control group) randomly,30 patients as the experimental group inhaled tiotropium 18 μg once every morning;30 patients as the control group took orally Theo-Dur 0.1g each time,twice a day for 4 weeks.Then testing the changing of patients' lung function before and after given the medicines above.Results Lung function of two groups were both improved,and the improvement of experimental group was obviously better than the control group(P < 0.05).Conclusion Patients with stable COPD regularly inhale tiotropium can obviously improve their lung function and clinical symptoms.
出处 《黑龙江医学》 2013年第8期693-694,共2页 Heilongjiang Medical Journal
关键词 噻托溴铵 慢性阻塞性肺疾病 肺功能分析 Tiotropium Chronic Obstructive Pulmonary Diaease(COPD) Pulmonary function analysis
  • 相关文献

参考文献5

二级参考文献18

  • 1有创-无创序贯机械通气多中心研究协作组.以肺部感染控制窗为切换点行有创与无创序贯机械通气治疗慢性阻塞性肺疾病所致严重呼吸衰竭的随机对照研究[J].中华结核和呼吸杂志,2006,29(1):14-18. 被引量:280
  • 2慢性阻塞性肺疾病诊治指南(2007年修订版)[J].中华结核和呼吸杂志,2007,30(1):8-17. 被引量:8245
  • 3KOUMIS T, SAMUEL S. Tiotropium bromide: a new long-acting bronchodilator for the treatment of chronic obstructive pulmonary disease. Clin Ther,2005,27 (4) :377-392.
  • 4panning CA, debisschop M. Tiotropium : an inhaled, long-acting anticholinergie drug for chronic obstructive pulmonary disease. Pharmacotherapy, 2003,23 ( 2 ) : 183 -189.
  • 5Donohue JF,Van Noord JA,Bateman ED,et al. A 6-month placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol. Chest,2002,122( 1 ) :47-55.
  • 6Halbert R J,Natoli J L,Gano A,et al.Global burden of COPD:systematic review and meta analysis[J].Eur Respir J,2006,28(1):523-532.
  • 7Decramer M,Celli B,Tashkin D P,et al.Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD:the UPLIFT trial[J].COPD,2004,1(2):303-312.
  • 8Pieper M P,Chaudhary N I,Park J E,Acetylcholine-induced proliferation of gibroblasts and myofibroblasts in vitro is inheibited by tiotropium bromide[J].Life Sci,2007,80(24-25):2270-2273.
  • 9Santus P,Centanni S,Morelli N,et al.Tiotropium is less likely to induce oxygen desaturation in alable COPD patients compared to long-acting beta(2.)-agonists[J].Respir Med,2007,101(8):1798-1803.
  • 10冉丕鑫 王辰 姚婉贞 等.我国部分地区慢性阻塞性肺疾病流行病学研究[J].中华结核和呼吸杂志,2007,.

共引文献1840

同被引文献25

引证文献6

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部