摘要
目的了解门诊癔球症患者症状与焦虑障碍的联系,比较分别予以口服质子泵抑制剂(PPI)与选择性5-羟色胺(5-HT)再摄取抑制剂(SSRIs)在治疗癔球症中的作用。方法以2008年5月至2009年9月女性癔球症患者29例和健康女志愿者30例为研究对象,将癔球症患者随机分配于口服埃索美拉唑组(15例)和帕罗西汀组(14例),记录每位患者治疗前后的症状、焦虑自评量表(SAS)评分,统计采用非参数检验。记录59例研究对象是否绝经、焦虑评级、年龄、文化程度、近3个月内有无重大负性事件和有无强迫症状,采用非条件Logistic回归分析危险因素。结果癔球症患者症状与焦虑评分具有显著一致性。治疗1周后随访,组内、组间比较口服帕罗西汀组改善症状优于埃索美拉唑。治疗3周后组内比较,帕罗西汀和埃索美拉唑改善症状评分均有统计学意义,前者显著改善SAS评分,后者则无;组间比较,帕罗西汀在改善症状和SAS评分皆优于埃索美拉唑,且有统计学意义。非条件Logistic回归分析示:焦虑、负性事件、绝经为密切相关危险因素。结论癔球症以绝经后女性多见,与焦虑状态相关。口服帕罗西汀改善症状短期内优于埃索美拉唑,治疗3周后,两种药物皆可改善癔球症症状,但帕罗西汀同时改善焦虑状态更优于埃索美拉唑。
Objective To understand the relation between the sympotoms of out-patients with globus and the anxiety disorsers, respectively compared to the oral PPI and SSRIs in the treatment of globus in the role. Methods To investigate female include 29 patients with globus and 30 cases of healthy volunteers in May 2008 ～ June 2009. Patients in globus were randomly assigned to the oral esomeprazole group ( 15 cases) and paroxetine ( 14 cases) group. Record the score of symptoms and SAS for each patient before and after treatment,which were compared and analysed by statistical non-parametric test. Record 59 patients and normal volunteers,of which,the menopause or not,anxiety rating,age,education level,are there the major negative events and obsessive-compulsive symptoms in nearly 3 months or not,which as risk factors were made in using non-conditional logistic regression analysis. Results The remarkable coherence for score of symptom and anxiety in patients with Globus. After 1 week treatment follow-up shows that Paroxetine is better than Esomeprazole to improve symptoms by comparison within-and inter-groups. Follow-up after treatment 3 weeks within group comparison,both paroxetine and Esomeprazole the group to improve the Globus symptoms were statistically significant,the former improved SAS score significantly,but the latter failed; between the two groups,paroxetine in improving significantly symptoms and the SAS score are better than esomeprazole statistically. logistic regression analysis results: anxiety,negative events,menopause as the closely related risk factors. Conclusions Globus in post-menopausal women with more common and related-anxiety. Short-term improvement of Globus symptoms of oral paroxetine is superior to esomeprazole. After the 3 weeks follow-up avaluation,two kinds of medicine can improve symptoms of Globus,while improve anxiety paroxetine is superior to esomeprazole.
出处
《中华临床医师杂志（电子版）》
CAS
2010年第6期772-775,共4页
Chinese Journal of Clinicians(Electronic Edition)
关键词
转换障碍
胃肠疾病
奥美拉唑
帕罗西汀
焦虑
Conversion disorder
Gastrointestinal diseases
Omeprazole
Paroxetine
Anxiety
