摘要
目的探讨高病毒载量慢性丙型肝炎抗病毒治疗的快速病毒学应答(RVR)预测因素。方法对55例高病毒载量(HCVRNA>1×105拷贝/ml)慢性丙型肝炎使用聚乙二醇干扰素α-2a联合利巴韦林进行抗病毒治疗者进行前瞻性研究,聚乙二醇干扰素α-2a135μg或180μg/次,皮下注射,每周1次,利巴韦林900～1200mg/d口服,于治疗前及治疗第4周检测HCVRNA定量,4周血清HCVRNA检测不到为获得RVR。采用Logistic多元回归分析RVR的影响因素,并比较治疗前不同病毒载量患者RVR的比例。结果 RVR与基线病毒载量呈负相关(B=-1.292)。基线HCVRNA≥1×105拷贝/ml且<1×107拷贝/ml者快速应答率为86.49%(32/37),基线HCVRNA≥1×107拷贝/ml者快速应答率为61.11%(11/18),两组比较有统计学差异(χ2=4.571,P=0.043)。结论基线HCVRNA水平可作为高病毒载量慢性丙型肝炎患者聚乙二醇干扰素联合利巴韦林治疗过程中RVR的预测因素,治疗前HCVRNA<1×107拷贝/ml者疗效较好。
Objective To survey the predictors of rapid virological response(RVR)during antiviral therapy of patients with chronic hepatitis C of high viral loads.Methods 55 patients with chronic hepatitis C of high viral loads were treated with peg-interferon α-2a and ribavirin.All patients received a combination of peg-interferon α-2a (180/135 μg/week,hypodermic injection)and ribavirin(900～1200 mg/d)for therapy.Liver functions and the level of HCV-RNA in baseline and the 4th week were detected during the therapy.Logistic regression analysis then was taken and comparison between groups of different viral loads was processed.Results Negative correlation between the baseline level of HCV RNA and RVR was shown(B=-1.292).Patients with baseline HCV RNA<1×107copies/ml got better RVR rate(86.49%,32/37),while the RVR rate of patients with baseline HCV RNA≥1×107copies/ml was 61.11%(11/18).Stasistical analysis showed significant difference (χ2=4.571,P=0.043).Conclusions The baseline HCV RNA load can be the predictor of RVR in antiviral therapy of patients with chronic hepatitis C of high viral loads.Patients with baseline HCV RNA level<1×107copies/ml will reach better efficacy.
出处
《中华临床医师杂志（电子版）》
CAS
2011年第18期5327-5330,共4页
Chinese Journal of Clinicians(Electronic Edition)
