摘要
目的探讨过敏性紫癜(HSP)患儿血D-二聚体(D-D)与尿微量蛋白的相关性,为HSP患儿的早期抗凝治疗提供可靠依据。方法对84例HSP患儿的血D-D、尿微量清蛋白(mAlb)、尿α1-微球蛋白(α1-M)等水平进行检测,并与30例门诊同期健康体检儿童的检测结果进行对比分析。结果观察组患儿中血D-D的阳性率为64.3%,尿mAlb、α1-M阳性率分别是59.5%、22.6%,与对照组相比差异有统计学意义(P<0.01);尿常规异常组血D-D、尿mAlb和α1-M含量与对照组相比,差异均具有统计学意义(P<0.05或P<0.01);尿常规正常组血D-D、尿mAlb和α1-M含量与对照组相比,差异亦有统计学意义(P<0.01);尿常规异常组尿mAlb和α1-M含量与尿常规正常组比较差异无统计学意义(P>0.05);54例血D-D异常者有53例(98.1%)尿mAlb和α1-M异常,30例血D-D正常者只有1例(3.3%)尿mAlb和α1-M异常,差异有统计学意义(P<0.01)。结论 HSP患儿机体高凝状态易并发肾损害,早期给予抗凝治疗,对预防过敏紫癜性肾炎(HSPN)的发生可能有一定帮助。
Objective This study was designed to investigate the correlations between serum D-dimer and wric microalbumin(mAlb) in children with Henoch-Schonlein purpura(HSP) and to provide a reliable basis for early anticoagulant therapy of HSP children.Methods 84 HSP children were included in the study,30 healthy children were considered as the control group.Serum D-dimer,uric mAlb and α1-M were analyzed.Results The positive rate of serum D-dimer in HSP children was 64.3%,the positive rate of the differences were and α1-M were 59.5% and 22.6%,respectively,compared with the control group,statistically significant(P<0.01).Serum D-dimer,uric mAlb and α1-M of abnormal routine urianlysis group and normal routine urianlysis group,compared with the control group,the differences were statistically significant(P<0.05).53 of 54 children with abnormal serum D-dimer were abnormal uric mAlb and α1-M.1 of 30 children with normal serum D-dimer was abnormal uric mAlb and α1-M.Conclusions HSP children with hypercoagulable state complicated by the body kidney damage.Giving anticoagulant therapy in early stage may be helpful to prevent the occurrence of allergic purpura nephritis.
出处
《中华临床医师杂志（电子版）》
CAS
2011年第13期3795-3798,共4页
Chinese Journal of Clinicians(Electronic Edition)
