摘要
生殖道人乳头瘤病毒 (HPV)感染是一种广泛流行的性传播疾病。高危型HPV持续感染被认为是宫颈癌及其癌前病变发生的主要因素。多重HPV感染、HPV病毒负荷与宫颈癌及其癌前病变的病变程度及发展密切相关。目前 ,对于宫颈HPV感染检测有多种手段 ,其中PCR和捕获杂交技术 (HCⅡ )在临床实验室应用较广泛。在宫颈癌的筛查中联合应用HPV检测和细胞学 ,可以提高敏感性、减少随诊频率 ,减少不必要的阴道镜检查。对于细胞学检查为不典型鳞状细胞(ASCUS)者 ,HPV检测可以帮助进一步区分高危人群。同时 ,HPV检测有可能作为一种有效的宫颈癌前病变及宫颈癌治疗后随访的预后指标。
Human papillomavirus(HPV)infection of genital tract is one of the most common sexually transmitted diseases in women worldwide.Persistent infection with high-risk human papillomavirus has been widely recognized to be the main cause of cervical intraepithelial neoplasia(CIN)and cervical cancer.Persistent HPV infection,infection with multiple HPV types,and HPV viral load are associated with development,progress,severity and size of squamous intraepithelial lesions and cervical cancer.There are now many methods of detecting HPV infection.In these methods,PCR and Hybird Capture Ⅱ(HCⅡ)have been in common use in the clinical laboratory.A combination of HPV testing and Pap smears in cervical cancer screening programs could increase the sensitivity,reduce the frequency of follow-up,and minimize unnecessary colposcopy.Especially in patients with ASCUS,HPV test may further identify those in high risk.Meanwhile HPV testing is a useful prognostic marker in the follow-up of patients with CIN and cervical cancer after treatment.
出处
《癌症进展》
2004年第5期331-338,共8页
Oncology Progress
作者简介
吴令英,通迅作者,(Corresponding author), E-mail: wuling ying@csco. org. cn
