摘要
目的研究轻度认知障碍患者单位数加法的心算效率及事件相关电位(ERP)早成分改变。方法被试者分为正常老年(对照)组和轻度认知障碍(MCI)组,每组16名,均为右利手。使用事件相关电位技术,采集单位数加法计算过程的脑电信号,比较两组行为数据和算式早成分(N1,P1,N170,P2)的波幅和潜伏期的差异。结果 MCI组的反应时间长于对照组,差异有显著性(P<0.01),正确率MCI组低于对照组,差异有显著性(P<0.01);MCI组与对照组比较,颞枕区N170以及额中央区P2潜伏期延长(P<0.01),波幅增大(P<0.05);MCI组左侧颞枕区N170波幅(-1.70μV)低于正常组(-2.96μV),差异具有显著性(P<0.01);MCI组右侧颞枕区N170波幅(-3.85μV)高于对照组(-0.75μV),差异具有显著性(P<0.01)。结论 MCI患者的单位数心算效率降低,计算的正确率降低,同时提示大脑在算式早期加工阶段出现异常。
Objective To study mental calculation efficiency and early components changes of event-related potentials on singledigit number addition of mild cognitive impairment (MCI) patients.Methods Sixteen healthy old men and 16 mild cognitive impairment patients served as subjects in this experiment.Behavioral data,mean amplitude and latency of early components of event-related potential(N1, P1,N170,P2)were compared between the two groups.Results The reaction time of MCI group was significantly longer than that of control group(P<0.01);The correct rate of MCI group was significantly lower than that of control group (P<0.01).Compared with the control group,the latency prolonged and the amplitude increased of the N170 in temporal-occipital region and P2 in central-frontal region in MCI group,N170 was significantly lower in left temporal-occipital region and higher in right temporal-occipital region in MCI group.Conclusion Patients with MCI have the deficit in single-digit number addition.The mechanism of early arithmetic calculation processing in MCI patients may be different from normal people.
出处
《潍坊医学院学报》
2009年第2期102-104,共3页
Acta Academiae Medicinae Weifang
基金
山东省自然科学基金资助项目(Y2008C125)
山东省教育厅科技计划项目(J08LH67)
关键词
认知障碍
轻度
事件相关电位
加法运算
Mild cognitive impairment
Event-related potentials(ERP)
Arithmetic calculation
作者简介
张媛媛(1982年～),女(汉族),山东省威海市人,在读硕士研究生.主要研究方向:神经电生理学.
李秀艳,E-mail:lixiuyan@163.com 通讯作者
