摘要
目的了解母源性抗-HBs对婴儿乙型肝炎疫苗接种后抗体应答的影响。方法定量检测43例抗-HBs阳性和29例抗-HBs阴性孕妇分娩前及其足月新生儿脐动脉血、第2针乙型肝炎疫苗接种前和接种后2.5个月的抗-HBs水平。结果43例抗-HBs阳性母亲所生新生儿脐血抗-HBs均阳性,其抗体水平与母体高度正相关(r=0.98,P<0.01),1月龄时仍有42例股静脉血抗体阳性;29例抗-HBs阴性母亲的新生儿脐血和1月龄时抗-HBs均阴性。第2针乙型肝炎疫苗接种后2.5个月,两组儿童抗-HBs阳性率均为100%,但母源性抗体阴性组平均抗-HBs活性浓度为163mIU/ml,明显高于母源性抗体阳性组的94mIU/ml(P<0.01);母源性抗-HBs大于1000mIU/ml的5名婴儿中,3名在接种第2针疫苗后没有产生主动抗体应答。结论母源性抗-HBs可抑制乙型肝炎疫苗前两针接种后的抗体应答。
Objective To clarify the effects of anti-HBs on the anti-body response to hepatitis B vaccine inoculation in infants.Methods Quantitative detection was performed on the umbilical arterial blood from 43 and 29 pregnant women who were positive and negative for anti-HBs respectively before delivery,and anti-HBs level in 2.5 months before and after the second Hepatitis B vaccine inoculation.Results Forty-three newborns whose women were positive for HBs were positive for anti-HBs in their cord blood,with positive correlation between the anti-HBs level and their mothers'(r=0.98,P<0.01).At 1 month of age,all these infants except one still remained protective level of anti-HBs.Twenty-nine newborns whose mothers were negative for anti-HBs were negative positive for anti-HBs in their cord blood at birth and 1 month of age.All the infants in the two group were positive for anti-HBs 2.5 months after hepatitis B vaccine inoculation.The mean concentration of anti-HBs in infants of mothers negative for anti-HBs were 163 mIU/ml,significantly higher than that of(94 mIU/ml) infants of mother positive for anti-HBs(P<0.01).Three of the 5 infants whose anti-HBS level were higher than 1 000 mIU/ml did not produce active antibody response after the second inoculation.Conclusion Passively acquired maternal anti-HBs in infants can inhibit active antibody response to hepatitis B vaccine.
出处
《解放军护理杂志》
2009年第10期1-4,共4页
Nursing Journal of Chinese People's Liberation Army
作者简介
魏素花( 1971-),女,江苏南京人,主管护师,大专,主要从事助产师的工作
