摘要
目的探讨乳果糖对肝硬化大鼠血泉内毒素(LPS)、肿瘤坏死因子(TNF)及血清ALT的影响。方法将四氯化碳(CCL_4)注射于SD大鼠皮下,诱导肝硬化伴腹水动物模型.将该鼠随机分为肝硬化模型组、乳果糖治疗组,检测各组和正常鼠的血浆LPS、TNF及血清ALT水平.结果肝硬化模型组LPS.TNF,ALT水平较正常对照组明显升高;乳果糖治疗组血浆LPS,TNF、ALT水平较肝硬化模型组明显降低.结论乳果糖能通过降低血浆LPS来显著降低TNF,对肝脏又保护作用.
Objective To study the effect of lactulose on plasm LPS,TNF in cirrhotic rats.Methods We injected CCL_4 oil solution into subcutane of SD rats to induce cirrhosis animal models with ascites.The rats were randomly divided into cirrhosis model group and treatment group with lactulose,We measured plasm LPS,TNF and serum ALT in every group and normal rats.Results Cirrhosis model group had significantly higher plasm LPS,TNF,serum ALT than those of in normal rats,Lactulose group had significantly lower LPS,TNF,serum ALT levels than those of cirrhosis model group.Conclusion Lactulose can reduce plasm LPS,TNF and protecthepatic cells.
出处
《中国医药指南》
2008年第17期4-5,共2页
Guide of China Medicine
