摘要
目的探讨Ki-67,p16在宫颈上皮内瘤样病变(CIN)的表达及其协助诊断的意义。方法应用免疫组化S-P法检测Ki-67,p16蛋白在慢性宫颈炎和CIN中的表达。结果Ki-67在宫颈炎、CIN1、CIN2和CIN3中阳性表达率为50%、47%、55%、77%;p16在宫颈炎、CIN1、CIN2、CIN3中的阳性表达率为41%、59%、72%、91%。Ki-67,p16的表达程度与CIN的级别有关(P<0.001);Ki-67,p16的表达程度在CIN3与CIN1及宫颈炎之间差异有统计学意义(P<0.05)。结论Ki-67,p16的表达与宫颈病变的程度有关。在日常工作中应借助二者的帮助对判断困难的宫颈病变标本进行诊断;同时,对有强阳性表达的较低级别的病例应进行随诊,以便及时观察处理。
Objective To investigate the Ki-67 and p16 protein expressions in the squamous intraepithelial lesions of the cervix.Methods S-P immunohistochemistry method was used to detect the expressions of Ki-67 and p16 in cervix samples.Results The positive rate of Ki-67 protein in the inflammatory lesions,CIN1,CIN2 and CIN3 were 50%,47%,55%,77%;The positive rate of p16 protein in the inflammatory lesions,CIN1,CIN2,CIN3 were 41%,59%,72%,91%.The expressions of Ki-67 and p16 protein were related to each other and corre...
出处
《首都医科大学学报》
CAS
2008年第3期344-347,共4页
Journal of Capital Medical University
基金
北京市西城区优秀人才专项经费(200405)资助项目~~
关键词
CIN
协助诊断
免疫组化
CIN
facilitation of diagnosis
immunohistochemistry
