摘要
目的探讨诺迪康胶囊在大鼠体内对茶碱药物动力学的影响。方法16只♂大鼠随机分为实验组和对照组。实验组ig给药诺迪康胶囊1 g.kg-17 d,对照组ig同剂量的生理盐水。第8天ig后30 min,iv氨茶碱(20 mg.kg-1),并于给药前与给药后0.25、0.5、1、2、4、6、8、10、12、24 h不同时间动脉采血,采用HPLC法测定血浆中的茶碱浓度。并比较两组间的药物动力学参数。结果诺迪康胶囊与氨茶碱合用后,在大鼠体内K值显著增大(P<0.05)、t1/2显著缩短(P<0.05)、Vd显著减小(P<0.05),但Cl和AUC无统计学差异(P>0.05)。结论在大鼠体内,诺迪康胶囊可加快茶碱的代谢,临床上合用诺迪康胶囊与茶碱时应监测茶碱的血药浓度。
OBJECTIVE To evaluate the effects of Nuodikang Capsule(NDK) on the pharmacokinetics of theophylline in rats.METHODS 16 male rats were divided randomly into normal saline(NS) control group and NDK treated group.NDK treated group was administered with NDK(1 g·kg-1)for 7 days,while the NS control group was administered with the same volume of normal saline.On the eighth day,30 minutes after oral administration of NS and NDK,intravenous injection of aminophylline(20 mg·kg-1) was given,and blood samples were col...
出处
《华西药学杂志》
CAS
CSCD
北大核心
2008年第4期433-435,共3页
West China Journal of Pharmaceutical Sciences
