摘要
目的探讨肿瘤转移抑制基因KAI1在肝细胞癌中的表达及其与肝癌患者临床病理特征之关系。方法应用免疫组织化学丝氨酸磷脂(SP)法,检测55例肝癌和9例良性肝组织中KAI1蛋白的表达。结果良性肝组织中KAI1蛋白阳性表达率明显高于肝癌组织中KAI1蛋白阳性表达率。KAI1蛋白的表达与远处转移相关,与癌组织分化程度显著相关。而与肝癌患者年龄、性别、甲胎蛋白(AFP)含量、肿瘤大小、乙型肝炎表面抗原(HbsAg)和门脉癌栓无关。结论KAI1的异常表达可能参与了肝癌的发生、发展,并对肿瘤转移的判断有一定指导意义。
Objective To investigate the expression of the metastasis suppressor gene KAI1 in human hepatocellular carcinoma (HCC) and the relationship between expression of KAI1 and their clinicopathological features.Methods The expressions of KAI1 in 55 patients with HCC and 9 benign hepatic diseases samples were detected by S-P immunohistochemistry.Results The positive rates of KAI1 were significantly higher in benign hepatic tissues than in HCC (88.9%, 33.7%,P<0.05).The expression of KAI1 had correlation with metastasis (P<0.05),and was strongly associated with differentiation of HCC cells (P<0.01).But the expression of KAI1 in HCC had no correlation with age,sex,value of AFP,tumor size and HbsAg.Conclusion The abnormal expression of KAI1 probably participates in genesis and development of HCC,and possesses clinical significance in evaluating the metastasis of HCC.
出处
《临床和实验医学杂志》
2006年第9期1285-1286,共2页
Journal of Clinical and Experimental Medicine
