CD4^+ CD25^+调节性T细胞及其在性传播疾病中的作用
被引量:1
摘要
CD4+CD25+调节性T细胞(CD4+CD25+Treg)是近年来确定的一类具有免疫抑制功能的T细胞亚群,可通过与细胞直接接触和分泌细胞因子如IL-10、TGF-β发挥调节作用,在维持机体免疫自稳、防止自身免疫以及抗感染免疫、肿瘤免疫、移植免疫、变态反应等方面起着重要作用。本文就CD4+CD25+Treg分化发育、表型、作用机制及其在性传播疾病中的作用作一综述。
出处
《岭南皮肤性病科杂志》
2006年第3期257-259,共3页
Southern China Journal of Dermato-Venereology
参考文献24
-
1[1]Sakaguchi S,Sakaguchi N,Asano M,et al.Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25).Breakdown of single mechanism of self-tolerance causes various autoimmune diseases[J].J Immunol,1995,155 (3):1151-1164.
-
2[2]Bluestone JA,Abbas AK.Natural versus adaptive regulatory T cells[J].Nat Revlmmunol,2003,3 (3):253-257.
-
3[3]Hori S,Nomura T,Sakaguchi S.Control of regulatory T cells development by the transcription factor Foxp3[J].Science,2003,299 (5609):1057-1061.
-
4[4]Brunkow ME,Jeffery EW,Hjerrild KA,et al.Disruption of a new forkhead/winged-helix protein,scurfin,results in the fatal lymphoproliferative disorder of the scurfy mouse[J].Nat Genet,2001,27(1):68 -73.
-
5[5]Roncador G,Brown PJ,Maestre L,et al.Analysis of FOXP3 protein expression in human CD4+ CD25+ regulatory T cells at the single-cell level[J].Eur J Immunol,2005,35(6):1681-1691.
-
6[6]Chen TC,Cobboled SP,Fairchild PJ,et al.Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen[J].J Immunol,2004,172(10):5900 -5907.
-
7[7]Choi BM,Pae HO,Jeong YR,et al.Critial role of heme oxgenase-1 in Foxp3-mediated immune suppression[J].Biochem Biophys Res Commun,2005,327 (4):1066-1071.
-
8[8]Cosmi L,Liotta F,Lazzeri E,et al.Human CD8+ CD25+ thymocytes share phenotypicand functional features with CD4+ CD25+ regulatory thumocytes[J].Blood,2003,102(12):4107-4114.
-
9[9]Ronchetti S,Zollo O,Bruscoli S,et al.GITR,a member of the TNF receptorsuperfamily,is co-stimulatory to mouse T lymphocyte subpopulations[J].Eur J Immunol,2004,34(3):613 -622.
-
10[10]Ji HB,Liao G,Faubion WA et al.Cutting edge:the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression[J].J Immunol,2004,172(10):5823-5827.
二级参考文献13
-
1Podwinska J.The role of humoral and cell-mediated immunity in protection against Treponema pallidum infection.Arch Immunol Ther Exp (Warsz),1993,41:281-284.
-
2Itoh M,Takahashi T,Sakaguchi N,et al.Thymus and autoimmunity:production of CD25+CD4+naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance.J Immunol,1999,162:5317-5326.
-
3Baecher-Allan C,Brown JA,Freeman GJ,et al.CD4^+CD25^high regulatory cells in human peripheral blood.J Immunol,2001,167:1245-1253.
-
4Suvas S,Kumaraguru U,Pack CD,et al.CD4^+CD25^+ T cells regulate virus-specific primary and memory CD8^+T cell responses.J Exp Med,2003,198:889-901.
-
5Hori S,Carvalho TL,Demengeot J.CD25^+CD4^+ regulatory T cells suppress CD4^+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice.Eur J Immunol,2002,32:1282-1291.
-
6Belkaid Y,Piccirillo CA,Mendez S,et al.CD4^+CD25^+ regulatory T cells control Leishmania major persistence and immunity.Nature,2002,420:502-507.
-
7Belkaid Y,Rouse BT.Natural regulatory T cells in infectious disease.Nat Immunol,2005,6:353-360.
-
8McGuirk P,McCann C,Mills KH.Pathogen-specific T regulatory1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells:a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis.J Exp Med,2002,195:221-231.
-
9MacDonald AJ,Duffy M,Brady MT,et al.CD4 T helper type 1and regulatory T cells induced against the same epitopes on the core protein in hepatitis C virus-infected persons.J Infect Dis,2002,185:720-727.
-
10Iwashiro M,Messer.RJ,Peterson KE,et al.Immunosuppression by CD4^+ regulatory T cells induced by chronic retroviral infection.Proc Natl Acad Sci USA,2001,98:9226-9230.
共引文献25
-
1陈蓉,胡治平,陈志斌,蔡美华,容琼文.短暂性脑缺血发作患者血清转化生长因子-β1的浓度变化及临床意义[J].中国现代医学杂志,2007,17(16):1931-1933. 被引量:1
-
2陈蓉,赵振强,容琼文.氟桂嗪对脑梗死患者血清转化生长因子-β_1的浓度影响[J].中国热带医学,2007,7(11):2037-2038.
-
3罗佐杰,谢新荣,秦映芬,马燕,邝晓聪,梁杏欢.CTLA-4基因微卫星多态性与广西地区汉族Graves病的相关性研究[J].中国现代医学杂志,2007,17(21):2609-2612. 被引量:1
-
4韩凌,黄琼,方栩,项蕾红,郑志忠.银屑病患者外周血调节性T细胞的检测[J].中华皮肤科杂志,2008,41(3):157-159. 被引量:2
-
5赵建斌,鞠强,李青,杨雪萍,张津萍,王千秋.梅毒患者外周血T细胞亚群的变化及与凋亡的关系[J].中国麻风皮肤病杂志,2008,24(7):543-544. 被引量:9
-
6郑和国,谢小玲,郭恩德,连少惠.梅毒血清固定患者36例临床分析[J].中国皮肤性病学杂志,2008,22(12):735-736. 被引量:16
-
7陶小华,王千秋.梅毒的临床免疫学研究进展[J].岭南皮肤性病科杂志,2009,16(1):65-67. 被引量:9
-
8魏培,孙万邦.CD4^+CD25^+T细胞的生物学特性和临床研究进展[J].公共卫生与预防医学,2009,20(2):50-52. 被引量:1
-
9刘晓霞,陈剑华,陈育民,王雪玲.八珍汤对TGF-β1抑制的T淋巴细胞增殖及其活化影响[J].细胞与分子免疫学杂志,2009,25(11):1053-1055. 被引量:12
-
10梁远飞,陈晓燕,张允奇.血清固定的隐性梅毒患者Treg细胞表达CD28/CD152分子的探讨[J].皮肤性病诊疗学杂志,2010,17(4):271-273. 被引量:2
同被引文献18
-
1陈昊,诸禹平,亓林,吴逵,周林玉,孙友文,肖峻.TGF-β抑制T细胞功能及其相关机制的体外研究[J].中国现代医学杂志,2005,15(21):3244-3247. 被引量:9
-
2杨江华,张永祥,苏川,孙南雄.慢性丙型肝炎患者CD4^+CD25^+调节性T细胞表达增加[J].世界华人消化杂志,2005,13(18):2201-2204. 被引量:10
-
3祖莹,李成荣,郑跃杰,邓继岿,付晓玲.CD4^+ CD25^+调节性T细胞在儿童哮喘发病机制中的作用初探[J].中华医学杂志,2006,86(1):35-38. 被引量:19
-
4杨江华,张永祥,王芳,喻荣彬,苏川,孙南雄.人外周血CD4^+ CD25^+调节性T细胞的分离、鉴定和功能特征[J].细胞与分子免疫学杂志,2006,22(2):252-254. 被引量:18
-
5韩梅,王冠军.CD4^+CD25^+免疫调节性T细胞对CD4^+T细胞介导的移植物抗宿主病预防作用的研究[J].中国免疫学杂志,2006,22(4):323-326. 被引量:6
-
6吴忆,刘军,冯辉,马世红,曹雅明.CD4^+CD25^+调节性T细胞在约氏疟原虫感染小鼠应答早期中的作用[J].中国人兽共患病学报,2006,22(6):571-574. 被引量:2
-
7刘荣军,葛棣,丁建勇,熊思东,赵强,张镭,储以微.肺癌患者CD4^+ CD25^(high) Foxp3^+调节性T细胞的格局变化及意义[J].中国免疫学杂志,2006,22(6):531-534. 被引量:20
-
8杨治芳,周智广,唐炜立,黄干,彭健,李霞,何凌.成人隐匿性自身免疫糖尿病CD4^+调节性T细胞研究[J].中华医学杂志,2006,86(36):2533-2536. 被引量:7
-
9Sakaguehi S, Sakaguchi N, Asano M, et al. Immunologieself-tolerance maintained by activated T cells expressingIL-2 receptor alphachains ( CD25 ). Breakdown of singlemechanism of self-tolerance causes various autoimmunediseases [J]. J Immunol, 1995, 155 (3) :1151 - 1164.
-
10Bluestone JA ,Abbas AK. Natural versus adaptive regulatory T cells [J].Nat RevImmunol, 2003,3 ( 3 ) : 253 - 257.
-
1梅杨,葛锐,潘发明,徐胜前.调节性T细胞与常见自身免疫性疾病[J].安徽医药,2010,14(3):249-252. 被引量:11
-
2卢雪红,田庚,杨巍,李一,顾华.MRL/lpr狼疮小鼠CD4^+ CD25^+调节性T细胞和相关基因的研究[J].中国老年学杂志,2010,30(9):1232-1234.
-
3吴振权,杨明,张海滨,李辽源,徐文峰,肖平,林哲,夏桃林.前列腺癌患者外周血CD4^+CD25^+调节性T细胞与Foxp3 mRNA的表达及临床意义[J].广东医学,2011,32(3):346-348. 被引量:1
-
4王昕,黄牛,朱雄兵,谢伟,王国洲,陈双倩,李华驰,马翔,冯茂辉.胃癌患者外周血CD4+CD25+调节性T细胞的变化及其意义[J].中华实验外科杂志,2015,32(9):2243-2245. 被引量:5
-
5阿依姆妮萨.阿卜杜热合曼,哈力达.亚森,赵芳,张雪,丁剑冰,马秀敏,郭新红.特发性血小板减少性紫癜患者CD4^+ CD25^+ Treg细胞和TGF-β1的相关研究[J].细胞与分子免疫学杂志,2010,26(9):895-897. 被引量:4
-
6唐春莲,郭思洁,杨进,祝青,刘晓宏.CD4+CD25+调节性T细胞在血吸虫免疫逃避中的作用及机制研究[J].国际免疫学杂志,2014,37(5):449-452.
-
7王天娇,赵孟,尹新华.Th17和Treg在心血管疾病中作用的研究进展[J].医学综述,2014,20(18):3341-3343. 被引量:2
-
8周剑,罗邦伟.人外周血单个核细胞来源CD4^+CD25^+调节性T细胞的体外扩增培养及功能研究[J].免疫学杂志,2014,30(6):504-507. 被引量:6
-
9孟宪春,王万海,明亮,贺付成.CD4+ CD25+调节性T细胞在慢性丙型肝炎病毒感染中的研究进展[J].细胞与分子免疫学杂志,2016,32(4):561-563. 被引量:1
-
10印永祥,韩晓枫,何阳.免疫磁珠两步法分离小鼠脾脏CD4^+CD25^+调节性T细胞[J].标记免疫分析与临床,2009,16(4):244-247. 被引量:2