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PTTG在结直肠癌组织中的表达及意义 被引量：1

Expression of PTTG and its significance in colorectal cancer
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摘要 目的探讨垂体瘤转化因子(PTTG)mRNA在结直肠癌发生、发展中的作用。方法应用RT-PCR法检测PTTG mRNA在44份结直肠癌、12份正常结直肠黏膜、20份结直肠腺瘤组织中的表达。结果PTTG mRNA在结直肠癌中的表达明显高于直肠腺瘤和正常直肠黏膜组织,结直肠癌Dukes C、D期者表达明显高于Dukes A、B期者,有淋巴结转移者明显高于无淋巴结转移者,P均<0.05。提示PTTG可能参与了结直肠癌的发生、发展,并对肿瘤转移有促进作用。 Objective To detect the expression and role of PTTG mRNA in human colorectal cancer.Methods The expression of PTTG mRNA was evaluated in 12 normal colorectal tissues,20 colorectal adenoma tissues and 44 colorectal cancer tissues by RT-PCR.Results The expression of PTTG mRNA in colorectal cancer was significantly higher than that in colorectal adenoma and normal colorectal tissues.The PTTG mRNA expression in the Dukes C,D colorectal cancer was higher than that in the Dukes A,B cancer(P<0.05).The expressio...
作者 王先丽 莫维光
机构地区 广西医科大学
出处 《山东医药》 CAS 北大核心 2008年第5期27-28,共2页 Shandong Medical Journal
基金 广西壮族自治区科技厅资助项目(桂科自0542070)
关键词 结直肠癌 垂体瘤转化基因 逆转录聚合酶链反应 colorectal cancer pituitary tumor transforminy gene RT-PCR
分类号 R735.3 [医药卫生—肿瘤]
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参考文献4

  • 1崔友强,滕良珠,李国新,曲元明.PTTG和bFGF在垂体瘤中的表达及临床意义[J].山东医药,2005,45(30):12-13. 被引量：8
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二级参考文献7

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共引文献7

同被引文献15

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山东医药
2008年 第5期

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