摘要
目的:埋藏式除颤器(ICD)能够降低有危及生命室性心律失常病史患者的心律失常性死亡率以及全因死亡率。然而,在老年患者中非心律失常性死亡的风险同样较高,因此ICD在老年患者中的临床效果尚不确定。方法和结果:汇总来自三项比较ICD与胺碘酮的二级预防试验的患者资料。根据年龄将患者分为<75岁和≥75岁两组。报道患者的特征并确定各组中ICD对全因死亡和心律失常性死亡的影响。通过评价交互作用项(年龄与治疗)确定年龄对这些结果的影响。
Aims: The implantable defibrillator(ICD) reduces arrhythmic and all-cause mortality in patients with a history of life-threatening ventricular arrhythmias. However, its effectiveness in elderly patients is uncertain, given their competing risk of nonarrhythmic death. Methods and results: Individual patient data from all three secondary prevention trials comparing the ICD to amiodarone were pooled. Patients were divided into two groups based on age< 75 and ≥ 75 years. Patient characteristics were reported...
