摘要
为探讨滇产粗根荨麻不同部位的镇痛抗炎活性,并作有效部位筛选,本文采用醋酸扭体法和角叉菜胶致大鼠足肿胀模型筛选有效部位。正丁醇部分(200 mg/kg)对醋酸诱发小鼠扭体有抑制作用与空白及溶媒对照组比较(P<0.05);水部分(100,200,400 mg/kg)对角叉菜胶致大鼠足肿胀有明显抑制作用,与空白及溶媒对照组比较(P<0.01);正丁醇部分(400 mg/kg)可减轻角叉菜胶致大鼠足肿胀,与空白及溶媒对照组比较(P<0.05)。滇产粗根荨麻正丁醇部分有一定的镇痛抗炎作用,水部分具较强抗炎作用。
To explore the antinociceptive and anti-inflammatory effects of different fractions of Urtica macrorrhiza Hand-Mazz,and identify the effective constiuents of Urtica macrorrhiza Hand-Mazz,the antinociceptive effect of different fractions of Urtica macrorrhiza Hand-Mazz was studied using the writhing test in mice.Anti-inflammation of different fractions of Urtica macrorrhiza Hand-Mazz was assessed by carageenin induced paw edema in rats;Oral administration of n-butanol extract from Urtica macrorrhiza Hand-Maz...
出处
《天然产物研究与开发》
CAS
CSCD
2008年第2期343-345,共3页
Natural Product Research and Development
基金
云南省教育厅科学技术基金重点项目(04Z294C)
关键词
滇产粗根荨麻
提取
镇痛
抗炎
Urtica macrorrhiza Hand-Mazz
fraction
antinociceptive
anti-inflammatory
