摘要
代谢相关脂肪性肝病(MAFLD)是一种严重威胁公众健康的疾病,其发病机制尚不清楚。肠道微生物群及其代谢产物对MAFLD的发展有重要影响。在这篇综述中,笔者主要强调肠道微生物群及其代谢产物影响MAFLD的关键机制,并阐述了通过益生菌、益生元、合生元和粪菌移植(FMT)调节肠道微生物群来治疗MAFLD的研究。
Metabolic-associated fatty liver disease(MAFLD)is a serious public health threat and its pathogenesis is still not completely clear.Studies have shown that the intestinal microbiota and its metabolites have an important role in the development of MAFLD.In this review,we focus on the key mechanisms by which the intestinal microbiota and its metabolites influence MAFLD.In addition,we also discuss the treatment of MAFLD by modulating the intestinal microbiota through probiotics,prebiotics,synbiotics,and fecal microbiota transplantation.
作者
张大涯
陈世锔
陈润祥
张晓冬
李达
白飞虎
Zhang Daya;Chen Shiju;Chen Runxiang;Zhang Xiaodong;Li Da;Bai Feihu(Graduate School,Hainan Medical University,Haikou 571199,China;Department of Gastroenterology,The Second Affiliated Hospital of Hainan Medical University,Haikou 570216,China;The Gastroenterology Clinical Medical Center of Hainan Province,Haikou 570216,China)
出处
《中华临床医师杂志（电子版）》
CAS
北大核心
2023年第7期828-833,共6页
Chinese Journal of Clinicians(Electronic Edition)
基金
海南省临床医学中心建设项目资助(2021818)
海南省院士团队创新中心建设项目资助(2022136)
海南省院士创新平台科研项目资金资助(YSPTZX202313)
海南省卫生健康行业科研项目资助(22A200078)
海南省研究生创新科研课题(Qhyb2022-133)
海南医学院研究生创新科研课题(HYYB2022A18)
关键词
代谢相关脂肪性肝病
肠道菌群
脂多糖
短链脂肪酸
胆碱
Metabolic-related fatty liver disease
Intestinal microbiota
Lipopolysaccharide
Short-chain fatty acids
Choline
作者简介
通信作者:白飞虎,Email:328473521@qq.com
