摘要
富血小板血浆作为骨与软骨愈合、慢性肌腱炎症治疗的辅助物,被运用在诸如肩袖修复、跟腱修复、前交叉韧带重建等外科手术中。在诸多文献中提及,白细胞在富血小板血浆的疗效中发挥重要作用,其中在骨关节炎治疗方面,增加白细胞浓度会促进炎症因子的表达和细胞的死亡从而影响治疗效果,降低白细胞浓度更有利于骨关节炎患者的恢复治疗;在肌腱疾病治疗方面,增加白细胞浓度更有利于急性肌腱疾病的治疗,降低白细胞浓度更有利于慢性肌腱疾病的治疗;在创面修复方面,增加白细胞浓度具有更强的抗菌作用也更有利于创面的愈合,降低白细胞浓度可能会导致创面的感染从而影响愈合效果。本文就目前发表文献中涉及白细胞含量对富血小板血浆治疗骨关节及软组织损伤作用影响的相关部分进行综述。
Platelet-rich plasma(PRP)is used in surgical procedures such as rotator cuff repair,Achilles tendon repair and anterior cruciate ligament reconstruction as an aid of treatment for healings of bone and cartilage as well as chronic inflammation of tendon.It has been mentioned in many literatures that white blood cells play an important role in the efficacy of PRP.In the treatment of osteoarthritis,increasing white blood cell concentration can promote the expression of inflammatory factors and cell death,thus affecting the therapeutic effect.Reducing white blood cell concentration is more conducive to the recovery treatment of osteoarthritis patients.In the treatment of tendon diseases,increasing the concentration of white blood cells is more conducive to the treatment of acute tendon diseases,and reducing the concentration of white blood cells is more conducive to the treatment of chronic tendon diseases.In terms of wound healing,increasing white blood cell concentration has stronger antibacterial effect and is also more conducive to wound healing,while decreasing white blood cell concentration may lead to wound infection and thus affect the healing effect.This paper reviewed the current literatures about the effects of leukocyte content on PRP in the treatment of bones,joints and soft tissue injuries.
作者
王泽勇
覃健
Wang Zeyong;Qin Jian(Department of Orthopedics,Sir Run Run Hospital,Nanjing Medical University,Nanjing 211100,China)
出处
《中华关节外科杂志（电子版）》
CAS
CSCD
2023年第5期684-688,共5页
Chinese Journal of Joint Surgery(Electronic Edition)
基金
南京市卫生科技发展专项资金项目(YKK21256)
关键词
白细胞
富血小板血浆
骨
关节
软组织损伤
治疗结果
Leukocytes
Platelet-rich plasma
Bone and bones
Joints
Soft tissue injuries
Treatment outcome
作者简介
通信作者:覃健,Email:qinjian@njmu.edu.cn
